Mouse Anti-GCGR Recombinant Antibody (clone 6.23V3) (CAT#: HPAB-0023-LS)
The antibody provides an anti-GCGR antibody capable of blocking GCGR binding to glucagon.
Specific Inquiry
Figure 1 A single dose of H6.23.v3 improves glucose tolerance in diabetic ZDF.
Figure 2 A single dose of H6.23.v3 provides acute reduction in blood glucose in Zucker Diabetic Fatty (ZDF) rats.
Figure 3 Blood glucose in db/db mice 24 hours after a single dose of H6.23v2.
The bar graphs show fasting blood glucose (mg/dL) versus H6.23v2 mAb (mg/kg) at various concentrations (mg/kg).
FuncS
Figure 4 The inhibition of glucagon-induced G6Pase gene expression in primary human heptocytes.
FuncS
Figure 5 Inhibition of ¹²⁵I glucagon binding to primary human hepatocytes by H6.23 series competitive antibodies.
Specifications
- Immunogen
- GCGR
- Host Species
- Mouse
- Derivation
- Phage display library
- Type
- Mouse IgG1 κ
- Specificity
- Human GCGR
- Species Reactivity
- Human
- Clone
- 6.23V3
- Applications
- WB, FC, FuncS
- Related Disease
- Diabetes mellitus
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Functional Assay.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 6.23V3"
See other products for "GCGR"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1786z | Mouse Anti-GCGR Recombinant Antibody (clone 40C5) | WB, ELISA | Mouse IgG1, κ |
| PABL-099 | Mouse Anti-GCGR Recombinant Antibody (clone mAb7) | ELISA, WB, FuncS | Mouse IgG |
| PABW-048 | Mouse Anti-GCGR Recombinant Antibody (clone HGR-2 F6) | Block | Mouse IgG |
| HPAB-1620LY | Human Anti-GCGR Recombinant Antibody (clone CBL034) | ELISA, IHC | Human IgG |
| HPAB-1621LY | Human Anti-GCGR Recombinant Antibody (clone CBL035) | ELISA, IHC | Human IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-048 | Mouse Anti-GCGR Recombinant Antibody (clone HGR-2 F6); scFv Fragment | Block | Mouse scFv |
| PSBL-477 | Recombinant Human Anti-GCGR Antibody scFv Fragment (mAb1) | WB, ELISA, FuncS | scFv |
| HPAB-1620LY-S(P) | Human Anti-GCGR Recombinant Antibody (clone CBL034); scFv Fragment | ELISA, IHC | Human scFv |
| HPAB-1621LY-S(P) | Human Anti-GCGR Recombinant Antibody (clone CBL035); scFv Fragment | ELISA, IHC | Human scFv |
| HPAB-1622LY-S(P) | Human Anti-GCGR Recombinant Antibody (clone CBL036); scFv Fragment | ELISA, IHC | Human scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-063CQ | Anti-Human GCGR Recombinant Antibody (mAb5) | ELISA, FC | |
| TAB-064CQ | Anti-Human GCGR Recombinant Antibody (3C7) | ELISA, FC, WB | |
| TAB-063CQ-F(E) | Anti-Human GCGR Recombinant Antibody Fab Fragment (mAb5) | ELISA, FC | |
| TAB-064CQ-F(E) | Anti-Human GCGR Recombinant Antibody Fab Fragment (3C7) | ELISA, FC, WB | |
| TAB-067CQ-F(E) | Mouse Anti-GCGR Recombinant Antibody; Fab Fragment (TAB-067CQ-F(E)) | ELISA, FC | Mouse Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-065CQ | Anti-Human GCGR Recombinant Antibody (H6.23v3) | ELISA, FC, WB | Human antibody |
| TAB-068CQ-S(P) | Human Anti-GCGR Recombinant Antibody; scFv Fragment (TAB-068CQ-S(P)) | ELISA, FC | Human scFv |
| TAB-069CQ-S(P) | Human Anti-GCGR Recombinant Antibody; scFv Fragment (TAB-069CQ-S(P)) | ELISA, FC | Human scFv |
| TAB-065CQ-F(E) | Anti-Human GCGR Recombinant Antibody Fab Fragment (H6.23v3) | ELISA, FC, WB | Human antibody |
| PABX-067-S (P) | Recombinant Mouse Anti-GR-2 Antibody scFv Fragment (F6) | WB, Neut, FuncS | scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-066CQ | Anti-Human GCGR Recombinant Antibody (3C7v11) | ELISA, FC, WB | Humanized antibody |
| TAB-066CQ-S(P) | Anti-Human GCGR Recombinant Antibody scFv Fragment (3C7v11) | ELISA, FC, WB | Humanized antibody |
| TAB-066CQ-F(E) | Anti-Human GCGR Recombinant Antibody Fab Fragment (3C7v11) | ELISA, FC, WB | Humanized antibody |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-113LC | Recombinant Anti-Human GCGR Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
MHC Tetramer for Cancer
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0023-LS-S(P) | Mouse Anti-GCGR Recombinant Antibody (clone 6.23V3); scFv Fragment | WB, FC | Mouse scFv |
| HPAB-1620LY-F(E) | Human Anti-GCGR Recombinant Antibody (clone CBL034); Fab Fragment | ELISA, IHC | Human Fab |
| HPAB-1621LY-F(E) | Human Anti-GCGR Recombinant Antibody (clone CBL035); Fab Fragment | ELISA, IHC | Human Fab |
| HPAB-1622LY-F(E) | Human Anti-GCGR Recombinant Antibody (clone CBL036); Fab Fragment | ELISA, IHC | Human Fab |
| HPAB-0105LY-F(E) | Human Anti-GCGR Recombinant Antibody; Fab Fragment (HPAB-0105LY-F(E)) | ELISA | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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