Anti-GD2 Antibody-Cytokine Fusion Protein, IgG (ch14.18)-GM-CSF (CAT#: ACFP-SH021)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-GD2 IgG to GM-CSF. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the GD2 as well as the biological activity of GM-CSF. This antibody-cytokine fusion protein retains the ability to induce ADCC and CDC activity. The fusion of GM-CSF to the antibody increased its cytotoxicity against NMB7 neuroblastoma cells by granulocytes isolated from neuroblastoma patients, and increased ADCC-mediated by mononuclear cells from the same patients, in comparison with ch14.18 alone. This immunocytokine was designed for treating GD2-positive tumors.
Specific Inquiry
Specifications
- Target
- GD2
- Molecule Class
- IgG1-GM-CSF
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- ch14.18
- Related Disease
- GD2-positive tumors
- Cytokine 1
- GM-CSF
- Cytokines 1 Description
- Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- Disialoganglioside GD2; Ganglioside G2; GD2
Downloads
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See other products for "Clone ch14.18"
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-770-sdAb | Recombinant Anti-Human GD2 VHH Single Domain Antibody | Neut, ChiP, IP, FUNC | Llama VHH |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-731 | Anti-GD2 Recombinant Antibody (Dinutuximab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 - kappa |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L018R | anti-GD2 immunotoxin 14G2a (IgG)-RTA | Cytotoxicity assay, Functional assay |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-304CL | Anti-Human GD2 Recombinant Antibody (hu14.18K322A) | FC, FuncS | Antibody |
| PABX-059 | Human Anti-GD2 Recombinant Antibody (PABX-059) | FuncS | IgG1, κ |
| PABX-059-F (E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (PABX-059-F (E)) | FC, ELISA, FuncS | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-100 | Mouse Anti-GD2 Recombinant Antibody (clone 14G2a) | ELISA, WB, FuncS | Mouse IgG |
| PABL-101 | Mouse Anti-GD2 Recombinant Antibody (clone 3F8) | FC, ELISA, FuncS | Mouse IgG |
| FAMAB-0126YC | Mouse Anti-GD2 Recombinant Antibody (clone 7A4) | ELISA | Mouse IgG3, κ |
| HPAB-0701-CN | Human Anti-GD2 Recombinant Antibody (clone AB527) | ELISA, FC, IHC, IF | Human IgM |
| HPAB-1030WJ | Human Anti-GD2 Recombinant Antibody (HPAB-1030WJ) | ELISA | Chimeric (mouse/human) IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-100 | Mouse Anti-GD2 Recombinant Antibody (clone 14G2a); Fab Fragment | ELISA, WB, FuncS | Mouse Fab |
| PFBL-101 | Mouse Anti-GD2 Recombinant Antibody (clone 3F8); Fab Fragment | FC, ELISA, FuncS | Mouse Fab |
| FAMAB-0126-YC-F(E) | Mouse Anti-GD2 Recombinant Antibody (clone 7A4); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0027-WJ-F(E) | Mouse Anti-GD2 Recombinant Antibody; Fab Fragment (HPAB-0027-WJ-F(E)) | ELISA, RIA | Mouse Fab |
| HPAB-1030WJ-F(E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (HPAB-1030WJ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-049 | Mouse Anti-GD2 Recombinant Antibody (clone ME36.1); scFv Fragment | WB, FuncS | Mouse scFv |
| MOB-181CQ | Human Anti-GD2 Recombinant Antibody (MOB-181CQ) | ELISA, FC, FuncS | Humanized scFv |
| FAMAB-0126-YC-S(P) | Mouse Anti-GD2 Recombinant Antibody (clone 7A4); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0701-CN-S(P) | Human Anti-GD2 Recombinant Antibody (clone AB527); scFv Fragment | ELISA, FC, IHC, IF | Human scFv |
| HPAB-0027-WJ-S(P) | Mouse Anti-GD2 Recombinant Antibody; scFv Fragment (HPAB-0027-WJ-S(P)) | ELISA, RIA | Mouse scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-074CQ-F(E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (TAB-074CQ-F(E)) | ELISA, FC | Human Fab |
| TAB-075CQ-F(E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (TAB-075CQ-F(E)) | ELISA, FC | Human Fab |
| TAB-076CQ-F(E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (TAB-076CQ-F(E)) | ELISA, FC | Human Fab |
| TAB-077CQ-F(E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (TAB-077CQ-F(E)) | ELISA, FC | Human Fab |
| TAB-078CQ-F(E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (TAB-078CQ-F(E)) | ELISA, FC | Human Fab |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-029CN | Mouse Anti-GD2 Recombinant Antibody (clone 5F11) | WB | Mouse IgG |
| NS-030CN | Mouse Anti-GD2 Recombinant Antibody (clone 3G6) | WB | Mouse IgG |
| NS-029CN-F(E) | Mouse Anti-GD2 Recombinant Antibody (clone 5F11); Fab Fragment | WB | Mouse Fab |
| NS-030CN-F(E) | Mouse Anti-GD2 Recombinant Antibody (clone 3G6); Fab Fragment | WB | Mouse Fab |
| NS-029CN-S(P) | Mouse Anti-GD2 Recombinant Antibody (clone 5F11); scFv Fragment | WB | Mouse scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-731 | Afuco™ Anti-GD2 ADCC Recombinant Antibody (Dinutuximab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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