Recombinant Human Anti-HCMV AD-2S1 epitope of gB Antibody (M2J1) (CAT#: PABW-056)
Recombinant Human Antibody (M2J1) is capable of binding to HCMV AD-2S1 epitope of gB, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HCMV AD-2S1 epitope of gB mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HCMV AD-2S1 epitope of gB mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. M2J1 itself is polyspecific and recognizes multiple autoantigens, although it nevertheless exhibited fine sequence specificity for AD-2S1 in that it failed to bind detectably to the homologous peptide from CCMV
Specific Inquiry
Figure 1 Rmsd of the two simulations.
Black indicates the mature rmsd of the backbone atoms after structural alignment of their Cα; the corresponding germline data are in red.
Di Palma, F., & Tramontano, A. (2017). Dynamics behind affinity maturation of an anti‐HCMV antibody family influencing antigen binding. FEBS letters, 591(18), 2936-2950.
Specifications
- Immunogen
- HCMV Envelope glycoprotein B
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native HCMV AD-2S1 epitope of gB
- Species Reactivity
- HCMV
- Clone
- M2J1
- Applications
- ELISA, Neut, FACS
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The gB antibody has been reported in applications of Stimulation.
Target
- Alternative Names
- gB; Envelope glycoprotein B; Env; Envelope; glycoprotein B
- UniProt ID
- P06473
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-114 | Recombinant Human Anti-HCMV glycoprotein B Antibody (1G2 ) | WB, ELISA, Neut, FuncS | IgG |
| PABL-115 | Recombinant Human Anti-HCMV Glycoprotein B Antibody (KE5) | WB, ELISA, IF, FuncS | IgG |
| PABL-116 | Recombinant Human Anti-HCMV glycoprotein B Antibody (SM5-1) | Neut, FuncS | IgG |
| PABZ-056 | Recombinant Human Anti-HCMV AD-2S1 epitope of gB Antibody (8F9) | ELISA, Neut, FACS | IgG |
| PABC-057 | Recombinant Human Anti-HCMV AD-2S1 epitope of gB Antibody (M2J5) | ELISA, Neut, FACS | IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-114 | Recombinant Human Anti-HCMV glycoprotein B Antibody Fab Fragment (1G2 ) | WB, ELISA, Neut, FuncS | Fab |
| PFBL-115 | Recombinant Human Anti-HCMV Glycoprotein B Antibody Fab Fragment (KE5) | WB, ELISA, IF, FuncS | Fab |
| PFBL-116 | Recombinant Human Anti-HCMV glycoprotein B Antibody Fab Fragment (SM5-1) | Neut, FuncS | Fab |
| PFBZ-056 | Recombinant Human Anti-HCMV AD-2S1 epitope of gB Antibody Fab Fragment (8F9) | ELISA, Neut, FACS | |
| PFBW-056 | Recombinant Human Anti-HCMV AD-2S1 epitope of gB Antibody Fab Fragment (M2J1) | ELISA, Neut, FACS |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-056 | Recombinant Human Anti-HCMV AD-2S1 epitope of gB Antibody scFv Fragment (8F9) | ELISA, Neut, FACS | scFv |
| PSBW-056 | Recombinant Human Anti-HCMV AD-2S1 epitope of gB Antibody scFv Fragment (M2J1) | ELISA, Neut, FACS | scFv |
| PSBC-057 | Recombinant Human Anti-HCMV AD-2S1 epitope of gB Antibody scFv Fragment (M2J5) | ELISA, Neut, FACS | scFv |
| FAMAB-0117-CN-S(P) | Recombinant Mouse Anti-gB Antibody scFv Fragment (HCMV37) | IP | Mouse scFv |
| FAMAB-0118-CN-S(P) | Recombinant Humanized Anti-gB Antibody scFv Fragment (HuHCMV37) | IP | Humanized scFv |
MHC Tetramer for Virology
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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