This product is a recombinant human anti-HIV-1 monoclonal antibody. 4E10-IgG3 specifically binds to gp41 and can be potentially used in the treatment of acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies.
Figure 1. Inhibition of HIV-1 infection in primary macrophages. All three MAbs were IgG; 4E10 served as a positive control, and the nonneutralizing anti-HIV-1 Mab A32 was used as a negative control.
Zhu, Z., Qin, H. R., Chen, W., Zhao, Q., Shen, X., Schutte, R., ... & Fouda, G. G. (2011). Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies. Journal of virology, 85(21), 11401-11408.
Figure 2. Antibody-dependent cell-mediated viral inhibition (ADCVI) of 2F5 and 4E10 in comparison to b12. Supernatant was collected and assayed for p27 by ELISA to measure viral inhibition.
Hessell, A. J., Rakasz, E. G., Tehrani, D. M., Huber, M., Weisgrau, K. L., Landucci, G., ... & Burton, D. R. (2010). Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L. Journal of virology, 84(3), 1302-1313.
Figure 1 Binding of 2F5 and 4E10 to peptides 2030, 2031, and gp160. Serial twofold dilutions of peptides were coated overnight on ELISA plates before incubation with constant amounts of 4E10 or 2F5 (100 ng/ml).
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-486-S(P) | Recombinant Anti-HIV-1 gp41 Antibody scFv Fragment | FC, WB, FuncS | scFv |
MHH-486-S(P) | Recombinant Human Anti-HIV-1 gp41 Antibody scFv Fragment | IF, Neut, FuncS | scFv |
PSBC-331 | Mouse Anti-HIV-1 gp41 Recombinant Antibody; scFv Fragment (PSBC-331) | Neut | Mouse scFv |
PABJ-0150-S(P) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone N6 FR3-03); scFv Fragment | ELISA, Neut | Human scFv |
PABJ-0179-S(P) | Human Anti-HIV-1 gp41 Recombinant Antibody; scFv Fragment (PABJ-0179-S(P)) | ELISA, Neut, FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MHH-486 | Recombinant Human Anti-HIV-1 gp41 Antibody | ELISA, IP, FuncS | IgG |
MRO-842CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 1911) | WB | Mouse IgG2a |
MRO-843CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 191) | WB | Mouse IgG2 |
MRO-844CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 10E9) | WB, RIPA, ELISA, IF | Mouse IgG1 |
MRO-845CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 10F6) | ELISA, WB, IP, IF | Mouse IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-187 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 3BC176); Fab Fragment | Neut, FuncS | Human Fab |
PFBL-188 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 3BC315); Fab Fragment | Neut, FuncS | Human Fab |
PFBL-189 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone m66); Fab Fragment | Neut, FuncS | Human Fab |
PFBL-190 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 13H11); Fab Fragment | WB, ELISA, FuncS | Human Fab |
PFBL-191 | Human Anti-HIV-1 gp41 MPER peptide Recombinant Antibody (clone 1E8); Fab Fragment | WB, ELISA, FuncS | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-025LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (4E10-IgG3) | ELISA | Human antibody |
MRO-026LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (4E10-IgG1) | ELISA | Human antibody |
MRO-040LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (M66.6) | ELISA | Human antibody |
MRO-074LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (W) | ELISA | Human antibody |
MRO-077LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (3D6) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC746 | A*2402/HIV-1 gp41 (RYLKDQQLL) MHC Tetramer | FCM |
There are currently no Customer reviews or questions for MRO-025LC. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.