Recombinant Human Antibody (268-D) is capable of binding to HIV-1 gp160, expressed in HEK 293 cells. As V3 residues Lys305, His308 and Arg315 are among the most variable residues in the V3 crown, specificity for their side chains makes mAb 268-D highly strain specific.
Figure 1 QES mutations at EnvBaL subunit interfaces are insufficient to prevent recognition by V3-targeting antibodies.
(A) Expi293F cells expressing wild-type BaL (gray), BaL-QES.i01 (magenta), or BaL-QES.i02 gp160 (purple) were incubated with anti-V3 region monoclonal antibodies (from left to right) 2442, 268-D IV, 39F, and 3074. Bound antibody was detected by flow cytometry (n = 3, means ± the SD). (B) Binding of V3-targeting antibodies to cells expressing wild-type (gray) or QES.i01.c01 (blue; containing additional core mutations that limit CD4 interactions) BaL Env. The data are means (n = 2), with error bars showing the range.
Heredia, J. D., Park, J., Choi, H., Gill, K. S., & Procko, E. (2019). Conformational engineering of HIV-1 Env based on mutational tolerance in the CD4 and PG16 bound states. Journal of virology, 93(11), e00219-19.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
PABL-177 | Human Anti-HIV-1 gp160 Recombinant Antibody (PABL-177) | WB, ELISA, Neut, FuncS | Human IgG |
PABL-178 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 3H+109L) | WB, ELISA, FuncS | Human IgG |
PABL-179 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone PGT128) | WB, ELISA, FuncS | Human IgG |
PABL-180 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC08C) | WB, ELISA, Neut, FuncS | Human IgG, κ |
PABL-181 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC13.01) | FC, Neut, FuncS | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-551 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC16.01); Fab Fragment | Neut | Human Fab |
PFBL-552 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC18.02); Fab Fragment | Neut | Human Fab |
PFBL-553 | Human Anti-HIV-1 gp160 Recombinant Antibody; Fab Fragment (PFBL-553) | Neut | Human Fab |
PFBL-554 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone Z258-VRC27.01); Fab Fragment | Neut | Human Fab |
PSBC-180 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 2558); scFv Fragment | ELISA, Neut | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-086LC | Anti-HIV-1 gp160 Recombinant Antibody (1C1) | ELISA | Mouse antibody |
MRO-087LC | Anti-HIV-1 gp160 Recombinant Antibody (1H9) | ELISA | Mouse antibody |
MRO-086LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (1C1) | ELISA | Mouse antibody |
MRO-087LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (1H9) | ELISA | Mouse antibody |
MRO-088LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (2D7) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-075LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (24G3) | ELISA | Human antibody |
MRO-080LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (81C7) | ELISA | Human antibody |
MRO-091LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (MAb CL1) | ELISA | Human antibody |
MRO-100LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (N7019b) | ELISA | Human antibody |
MRO-101LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (K24-3b) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-3846CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone B15); scFv Fragment | ELISA, WB | Mouse scFv |
MRO-3847CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone C12); scFv Fragment | ELISA, WB, IP | Mouse scFv |
MRO-3848CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone C4); scFv Fragment | ELISA, WB | Mouse scFv |
MRO-4041CQ-S(P) | Rat Anti-HIV-1 gp160 Recombinant Antibody (clone 8/64b); scFv Fragment | Neut | Rat scFv |
MRO-4042CQ-S(P) | Rat Anti-HIV-1 gp160 Recombinant Antibody (clone 10/36e); scFv Fragment | Neut | Rat scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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