Anti-HIV Vif Intrabody [(D-Arg)9] (IAB-B036(A))

Recombinant anti-HIV Vif intrabody linked to (D-Arg)9 works within cells to bind HIV Vif, expressed in CHO cells. This intrabody efficiently bound Vif protein and neutralized its infectivity-enhancing function. Intrabody-expressing cells were shown to be highly refractory to challenge with different strains of HIV-1 and HIV-1-infected cells.      

Human immunodeficiency virus type 1 (HIV-1)-encoded Vif protein
Cell Penetrating Peptide
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
Species Reactivity
Antibody assay: Enzyme-linked Immunosorbent Assay; Immunocytochemistry; Functional studies
Alternative Names
HIV vif; SOR protein; Virion infectivity factor
Entrez Gene ID

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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