Anti-Human Hla Recombinant Antibody (MEDI4893) (CAT#: TAB-358CL)
Recombinant Human monoclonal antibody expressed in CHO binding to Human Hla. MEDI4893 is a neutralizing human monoclonal antibody that targets α-toxin (AT) and is currently undergoing evaluation in the field of Staphylococcus aureus-mediated diseases. In particular, MEDI4893 not only sterically blocks binding of AT to its cell receptor but also prevents it from adopting a lytic heptameric trans-membrane conformation.
Specific Inquiry
FuncS
Figure 1 MEDI4893 pharmacokinetics in healthy adult volunteers.
Dashed line, the target concentration of 211 µg/ml, which is the EC₉₀ from a S. aureus murine pneumonia model.
Yu, X. Q., Robbie, G. J., Wu, Y., Esser, M. T., Jensen, K., Schwartz, H. I., ... & Jafri, H. S. (2017). Safety, tolerability, and pharmacokinetics of MEDI4893, an investigational, extended-half-life, anti-Staphylococcus aureus alpha-toxin human monoclonal antibody, in healthy adults. Antimicrobial agents and chemotherapy, 61(1), e01020-16.
Neut
Figure 2 Anti-alpha-toxin antibody levels in the three different subject populations (including healthy controls).
Anti-alpha-toxin-neutralizing Ab levels were measured in an RBC-based toxin neutralization assay.
Sharma-Kuinkel, B. K., Wu, Y., Tabor, D. E., Mok, H., Sellman, B. R., Jenkins, A., ... & Schell, W. A. (2015). Characterization of alpha-toxin hla gene variants, alpha-toxin expression levels, and levels of antibody to alpha-toxin in hemodialysis and postsurgical patients with Staphylococcus aureus bacteremia. Journal of clinical microbiology, 53(1), 227-236.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- FuncS, Neut
- Related Disease
- S. aureus pneumonia
Product Property
- Purity
- Purity>95% by SDS-PAGE
- Storage
- ≥1 year at -20°C. If the reconstituted antibody cannot be used within two weeks, it should be aliquoted into smaller vials and stored at -20°C
Applications
- Application Notes
- This antibody has been tested for use in Functional Assay and Neutralization. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- Staphylococcus aureus alpha toxin; Hla; Alpha-toxin; alpha-hemolysin
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-332 | Recombinant Human Anti-S.Aureus a-hemolysin Antibody | WB, ELISA, IF, FuncS | IgG |
| PABL-396 | Recombinant Human Anti-S. aureus Hla Antibody (MEDI4893) | BL | IgG |
| PABL-696 | Recombinant Human Anti-S. aureus a-hemolysin Antibody | WB, IHC, IF, FuncS | IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-332 | Recombinant Human Anti-S.Aureus a-hemolysin Antibody scFv Fragment | WB, ELISA, IF, FuncS | scFv |
| PSBL-395 | Recombinant Human Anti-S. aureus Hla Antibody scFv Fragment (MEDI4893) | BL | scFv |
| PSBL-689 | Recombinant Human Anti-S. aureus a-hemolysin Antibody scFv Fragment | WB, IHC, IF, FuncS | scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-332 | Recombinant Human Anti-S.Aureus a-hemolysin Antibody Fab Fragment | WB, ELISA, IF, FuncS | Fab |
| PFBL-395 | Recombinant Human Anti-S. aureus Hla Antibody Fab Fragment (MEDI4893) | BL | Fab |
| PFBL-689 | Recombinant Human Anti-S. aureus a-hemolysin Antibody Fab Fragment | WB, IHC, IF, FuncS | Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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