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Recombinant Mouse anti-Human PKD2 Monoclonal antibody (EML623) (CAT#: MOB-1621CT)

Recombinant Mouse monoclonal antibody to Human PKD2, expressed in Chinese Hamster Ovary cells(CHO).


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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line BJ
Figure 1 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line BJ shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15794/1743_H4_18_cr57ff7a365bc9d_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol & endoplasmic reticulum.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55297/907_C8_3_selected.jpg
Figure 3 IHC staining of human kidney
Figure 3 IHC staining of human kidney
(Immunohistochemical staining of human kidney shows cytoplasmic positivity in cells in tubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15794/37909_A_8_5_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Figure 4 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15794/37909_B_8_5.jpg
Figure 5 Colon
Figure 5 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15794/37909_A_9_3.jpg
Figure 6 Liver
Figure 6 Liver
(Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15794/37909_A_9_4.jpg
Figure 7 Kidney
Figure 7 Kidney
(Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15794/37909_A_8_5.jpg
Figure 8 Testis
Figure 8 Testis
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15794/37909_A_5_6.jpg
Figure 9 Lymph node
Figure 9 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15794/37909_A_9_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166)
Figure 10 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000118762-PKD2

Specifications

  • Immunogen
  • Recombinant fragment: PVSKTEKTNF KTLSSMEDFW KFTEGSLLDG LYWKMQPSNQ TEADNRSFIF YENLLLGVPR IRQLRVRNGS CSIPQDLRDE IKECYDVYSV SSEDRAPFGP , corresponding to amino acids 261-361 of Human Polycystin 2
  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • EML623
  • Applications
  • Used for immunoassay techniques such as: Western Blot
  • Conjugate
  • Unconjugated

Product Property

  • Purity
  • Protein G purified
  • Format
  • Liquid
  • Concentration
  • 1.0 mg/ml
  • Buffer
  • Preservative: None PBS, pH 7.2
  • Storage
  • Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Target

  • Alternative Names
  • PKD2; polycystic kidney disease 2 (autosomal dominant); PC2; PKD4; Pc-2; APKD2; TRPP2; polycystin-2; R48321; polycystwin; autosomal dominant polycystic kidney disease type II protein; transient receptor potential cation channel, subfamily P, member 2;
  • Function
  • ATPase binding; calcium ion binding; channel activity; cytoskeletal protein binding; ion channel activity; potassium channel activity; protein binding; receptor binding; voltage-gated chloride channel activity; voltage-gated sodium channel activity;

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Recombinant Antibody

CAT Product Name Application Type
VS3-WK946 Rabbit Anti-PKD2 Recombinant Antibody (VS3-WK946) WB Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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