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Anti-IAV NP Intrabody [Tat] (IAB-B040(T))

Recombinant anti-IAV NP intrabody in fusion with HIV Tat works within cells and is directed against IAV NP, expressed in E. coli cells. Anti-nucleoprotein intrabodies changed their cellular distribution in association with the viral nucleoprotein.      

Specifications
Immunogen
Influenza A virus nucleoprotein
Host
human
Type
scFv-Tat
Cell Penetrating Peptide
TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
Species Reactivity
IAV
Applications
Used for immunoassay techniques such as: Immunofluorescence; Flow Cytometry; Functional studies
Target
Alternative Names
IAV NP; Influenza A virus nucleoprotein; Common flu NP; Influenza A virus NP; NP; Nucleocapsid protein; Nucleoprotein; Protein N

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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