Afuco™ Anti-Human Integrin α5β3 ADCC Recombinant Antibody (VPI-2690B), ADCC Enhanced (CAT#: AFC-426CL)
Anti-Integrin α5β3 ADCC Enhanced Antibody (VPI-2690B) is an ADCC enhanced antibody produced by our Afuco™ platform. VPI-2690B is a first-in-class subcutaneously (under the skin) administered monoclonal antibody with a unique mechanism of action. VPI-2690B binds to a very specific target in the kidney, the C-loop domain sequence within a cell's α5β3 receptor. To date, Vascular Pharmaceuticals has completed an ascending single/multiple dose Phase 1 study of VPI-2690B in healthy volunteers. The results showed that the drug is safe with significant levels of drug exposure and exhibited a consistent, predictable safety profile. A Phase 2 clinical trial is currently ongoing and is enrolling new patients.
Specific Inquiry
Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Diabetic Nephropathy
Product Property
- Purity
- >90% assessed by SDS-PAGE
- Storage
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Target
- Alternative Names
- Integrin α5β3; Integrin alphaV beta3; ITGB3; ITGAV; ITGB3; BDPLT16; BDPLT2; CD61; GP3A; GPIIIa; GT
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-444CL | Human Anti-Integrin α5β3 Recombinant Antibody (TAB-444CL) | ELISA | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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