Anti-Human MCAM Recombinant Antibody (ABX-MA1) (CAT#: TAB-516CL)
Recombinant Human monoclonal antibody expressed in CHO binding to Human MCAM. ABX-MA1 is a fully human anti-MUC18 antibody relates to angiogenesis, tumor growth, and metastasis. ABX-MA1 treatment of melanoma cells in vitro significantly inhibited the promoter and collagenase activity of matrix metalloproteinase 2, resulting in decreased invasion through Matrigel-coated filters. ABX-MA1 directly disrupted the tube-like formation by HUVECs in an in vitro vessel formation assay. Collectively, these results point to usefulness of ABX-MA1 as a modality to treat melanoma either alone or in combination with conventional chemotherapy or other antitumor agents.
Specific Inquiry
WB
Figure 1 Western blot analysis of MUC18/MCAM in melanoma cell lines and HUVECs by ABX-MA1.
Mills, L., Tellez, C., Huang, S., Baker, C., McCarty, M., Green, L., ... & Bar-Eli, M. (2002). Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma. Cancer research, 62(17), 5106-5114.
FuncS
Figure 2 Effect of ABX-MA1 on attachment of melanoma cells to HUVECs.
A375SM cells were cocultured with HUVECs in the presence of ABX-MA1. A375SM attached to HUVECs, and this interaction was inhibited by ABX-MA1.
Mills, L., Tellez, C., Huang, S., Baker, C., McCarty, M., Green, L., ... & Bar-Eli, M. (2002). Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma. Cancer research, 62(17), 5106-5114.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- WB, FuncS
- Related Disease
- Melanoma
Product Property
- Purity
- >95% as judged by SDS-polyacrylamide gel electrophoresis
- Storage
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Applications
- Application Notes
- This antibody has been tested for use in Functional Assay and Western Blot. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- MCAM; melanoma cell adhesion molecule; CD146; MUC18; cell surface glycoprotein MUC18; Gicerin; melanoma adhesion molecule; cell surface glycoprotein P1H12; melanoma-associated antigen A32; melanoma-associated antigen MUC18; S-endo 1 endothelial-associated
- Gene ID
- 4162
- UniProt ID
- A0A024R3I5
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "MCAM"
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-441MZ | Mouse Anti-MCAM Recombinant Antibody (TAB-441MZ) | FC, FuncS | Mouse IgG1 |
| TAB-441MZ-S(P) | Mouse Anti-MCAM Recombinant Antibody; scFv Fragment (TAB-441MZ-S(P)) | FC, WB, IHC | Mouse scFv |
| TAB-441MZ-F(E) | Mouse Anti-MCAM Recombinant Antibody; Fab Fragment (TAB-441MZ-F(E)) | FC, WB, IHC | Mouse Fab |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-442MZ | Human Anti-MCAM Recombinant Antibody (TAB-442MZ) | FC, WB, IHC | Chimeric (Mouse/Human) IgG1 |
| TAB-443MZ | Human Anti-MCAM Recombinant Antibody (TAB-443MZ) | FC, WB, IHC | Chimeric (Mouse/Human) IgG3 |
| TAB-442MZ-S(P) | Human Anti-MCAM Recombinant Antibody; scFv Fragment (TAB-442MZ-S(P)) | FC, WB, IHC | Human scFv |
| TAB-443MZ-S(P) | Human Anti-MCAM Recombinant Antibody; scFv Fragment (TAB-443MZ-S(P)) | FC, WB, IHC | Human scFv |
| TAB-442MZ-F(E) | Human Anti-MCAM Recombinant Antibody; Fab Fragment (TAB-442MZ-F(E)) | FC, WB, IHC | Chimeric (Mouse/Human) Fab |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-444MZ | Anti-Human MCAM Recombinant Antibody (huAA98) | ELISA | Humanized antibody |
| TAB-444MZ-S(P) | Anti-Human MCAM Recombinant Antibody scFv Fragment (huAA98) | ELISA | Humanized antibody |
| TAB-444MZ-F(E) | Anti-Human MCAM Recombinant Antibody Fab Fragment (huAA98) | ELISA | Humanized antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0382CT | Recombinant Mouse anti-Human MCAM Monoclonal antibody (O2349) | IHC-P, WB | |
| FAMAB-0018-CN | Mouse Anti-MCAM Recombinant Antibody (clone c264) | FC | Mouse IgG |
| HPAB-0493LY | Human Anti-MCAM Recombinant Antibody (clone H5L0) | ELISA | Humanized IgG1 |
| HPAB-0494LY | Human Anti-MCAM Recombinant Antibody (clone H10L2) | ELISA | Humanized IgG1 |
| HPAB-0495LY | Human Anti-MCAM Recombinant Antibody (clone H14L0) | ELISA | Humanized IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2188 | Hi-Affi™ Recombinant Rabbit Anti-MCAM Monoclonal Antibody (DS2188AB) | ICC/IF, IHC-Fr, WB, IP, IHC-P, ICC, FC | IgG |
| MOR-4644 | Hi-Affi™ Recombinant Rabbit Anti-MCAM Monoclonal Antibody (TH157DS) | WB | IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0018-CN-F(E) | Mouse Anti-MCAM Recombinant Antibody (clone c264); Fab Fragment | FC | Mouse Fab |
| HPAB-0493LY-F(E) | Human Anti-MCAM Recombinant Antibody (clone H5L0); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0494LY-F(E) | Human Anti-MCAM Recombinant Antibody (clone H10L2); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0495LY-F(E) | Human Anti-MCAM Recombinant Antibody (clone H14L0); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0496LY-F(E) | Human Anti-MCAM Recombinant Antibody (clone H11L3); Fab Fragment | ELISA | Humanized Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0031-YJ-S(P) | Mouse Anti-MCAM Recombinant Antibody (clone AA98); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-1127WJ-S(P) | Mouse Anti-MCAM Recombinant Antibody (clone C3.19.1); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1128WJ-S(P) | Mouse Anti-MCAM Recombinant Antibody (clone C6.11.3); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1129WJ-S(P) | Mouse Anti-MCAM Recombinant Antibody (clone C3.10); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1176WJ-S(P) | Human Anti-MCAM Recombinant Antibody (clone c3.19.1); scFv Fragment | Inhib, ELISA | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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