Products

Anti-MHC class II Immunocytokine, IgG (chCLL-1)-GM-CSF (ACFP-SH024)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-MHC class II IgG to GM-CSF. It was expressed in CHO and purified with affinity chromatography. This antibody-cytokine fusion protein retains GM-CSF bioactivity, evaluated by its ability to induce the formation of hematopoietic progenitor colonies from bone marrow mononuclear cells, and also retains the ability to bind the antigens on the surface of cancer cells that express MHC class II. It also demonstrated ADCC in vitro, using human mononuclear cells as effectors. This immunocytokine was designed for treating B-cell NHL and chronic lymphocytic leukemia.      

Specifications
Target
MHC class II
Molecule Class
IgG1-GM-CSF
Species Reactivity
Human
Host
Chimeric (Human-Mouse)
Expression Host
CHO
Clone
chCLL-1
Related Disease
B-cell NHL and chronic lymphocytic leukemia
Cytokines 1
GM-CSF
Cytokines 1 Description
Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
DPB1; HLA DP1B; HLA-DPB1; Major histocompatibility complex class II DP beta 1; MHC class II antigen; MHC DPB1; MHC class II; I-Ek

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Send Inquiry Now!
Name:
* Phone:
* E-mail Address:
* Service & Products Interested:
Project Description:
* Verification Code:
Please input "biolabs"(case insensitive) as verification code.
Contact Us to Order
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

45-1 Ramsey Road, Shirley, NY 11967, USA     Tel: 1-631-871-5806    Fax: 1-631-207-8356    Email:
Terms of Service-Privacy Policy     © 2007 - 2017 Creative-Biolabs All Rights Reserved