Recombinant Chimeric (Human/Mouse) Antibody (8-18C5) is capable of binding to Rat MOG (myelin oligodendrocyte glycoprotein).
Figure 1 Western blot analysis of MOG expression in cell lysates from LN18MOG and LN18Ctr cells in nonreducing condition.
The 8-18C5 mAb stains two proteins corresponding to monomeric and dimeric MOG.
Zhou, D., Srivastava, R., Nessler, S., Grummel, V., Sommer, N., Brück, W., ... & Hemmer, B. (2006). Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis. Proceedings of the National Academy of Sciences, 103(50), 19057-19062.
Figure 2 Recombinant expression of native MOG to determine antibody binding.
Immunocytochemistry of LN18MOG (×200) by 8-18C5 mAb.
Zhou, D., Srivastava, R., Nessler, S., Grummel, V., Sommer, N., Brück, W., ... & Hemmer, B. (2006). Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis. Proceedings of the National Academy of Sciences, 103(50), 19057-19062.
Figure 3 Human antibodies to native MOG bind to intact myelin.
Rat brain slices were stained with 8–18C5 mAb. Staining was visualized by an anti-IgG antibody labeled with Alexa Fluor 488. Magnification: ×100
Zhou, D., Srivastava, R., Nessler, S., Grummel, V., Sommer, N., Brück, W., ... & Hemmer, B. (2006). Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis. Proceedings of the National Academy of Sciences, 103(50), 19057-19062.
Figure 4 Human antinative MOG antibodies induce demyelination and axonal damage in rat EAE.
EAE was induced in Lewis rats, and different sera or 8–18C5 mAb were injected intravenously.
Zhou, D., Srivastava, R., Nessler, S., Grummel, V., Sommer, N., Brück, W., ... & Hemmer, B. (2006). Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis. Proceedings of the National Academy of Sciences, 103(50), 19057-19062.
Figure 5 Human antibodies to native MOG induce cell death of MOG-expressing target cells.
LN18MOG (gray bars) and LN18Ctr (black bars) cells were incubated with anti-MOG antibody-positive and -negative MS sera. 8-18C5 mAb supplemented by serum from an antibody-negative patient was used as control.
Zhou, D., Srivastava, R., Nessler, S., Grummel, V., Sommer, N., Brück, W., ... & Hemmer, B. (2006). Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis. Proceedings of the National Academy of Sciences, 103(50), 19057-19062.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-670 | Recombinant Anti-human MOG Antibody | WB, FC, FuncS | IgG |
PABZ-152 | Mouse Anti-MOG Recombinant Antibody (clone 8-18C5) | WB | Mouse IgG1 |
FAMAB-0006WJ | Chimeric (mouse/human) Anti-MOG Recombinant Antibody (clone h8-18C5) | IF, FC, ELISA | Chimeric (mouse/human) IgG |
FAMAB-0228JF | Monkey Anti-MOG Recombinant Antibody (clone M12E) | WB, ELISA, IHC | Monkey Fab |
FAMAB-0229JF | Monkey Anti-MOG Recombinant Antibody (clone M3-24) | WB, ELISA, IHC | Monkey Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-670-F(E) | Recombinant Anti-human MOG Antibody Fab Fragment | Neut, IF, FuncS | Fab |
HPAB-1774-FY-S(P) | Human Anti-MOG Recombinant Antibody (clone AB138); Fab Fragment | Neut | Chimeric (marmoset/human) Fab |
FAMAB-0006WJ-F(E) | Chimeric (mouse/human) Anti-MOG Recombinant Antibody (clone h8-18C5); Fab Fragment | ELISA | Chimeric (mouse/human) Fab |
FAMAB-0228JF-F(E) | Monkey Anti-MOG Recombinant Antibody (clone M12E); Fab Fragment | ELISA, FuncS | Monkey Fab |
FAMAB-0229JF-F(E) | Monkey Anti-MOG Recombinant Antibody (clone M3-24); Fab Fragment | ELISA, FuncS | Monkey Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MHH-670-S(P) | Recombinant Human Anti-human MOG Antibody scFv Fragment | FC, ELISA, FuncS | scFv |
PSBZ-152 | Mouse Anti-MOG Recombinant Antibody (clone 8-18C5); scFv Fragment | WB | Mouse scFv |
FAMAB-0006WJ-S(P) | Chimeric (mouse/human) Anti-MOG Recombinant Antibody (clone h8-18C5); scFv Fragment | ELISA | Chimeric (mouse/human) scFv |
FAMAB-0228JF-S(P) | Monkey Anti-MOG Recombinant Antibody (clone M12E); scFv Fragment | ELISA, FuncS | Monkey scFv |
FAMAB-0229JF-S(P) | Monkey Anti-MOG Recombinant Antibody (clone M3-24); scFv Fragment | ELISA, FuncS | Monkey scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC661 | I-Ab/Mouse MOG (MEVGWYRSPFSRVVHLYRNGK) MHC Tetramer, APC | FC | |
MHC-LC702 | I-Ab/Mouse MOG (MEVGWYRSPFSRVVHLYRNGK) MHC Tetramer, PE | FC | |
MHC-LC926 | IAb/Mouse MOG (MEVGWYRSPFSRVVHLYRNGK) MHC Monomer | MHC Multimer | |
MHC-YF1586 | BV421-H-2 IAb/Mouse MOG (GWYRSPFSRVVH) MHC Tetramer | FC |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2266 | Hi-Affi™ Recombinant Rabbit Anti-MOG Monoclonal Antibody (DS2266AB) | WB, IHC, ICC | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC1988 | PE-DRB1*15:01/Human MOG (MEVGWYRPPFSRVVHLYRNGK) MHC Tetramer | FCM | |
MHC-CN0317 | APC-H-2Db/Human MOG (VGWYRSPFSRVVHL) MHC Tetramer | FCM | |
MHC-CN0318 | PE-H-2Db/Human MOG (VGWYRSPFSRVVHL) MHC Tetramer | FCM | |
MHC-YF305 | IAb/Human MOG (GWYRSPFSRVVH) MHC Monomer | MHC Multimer | |
MHC-YF307 | IAb/Human MOG (MEVGWYRSPFSRVVHLYRNGK) MHC Monomer | MHC Multimer |
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