Recombinant Mouse Antibody (sAB A8) is capable of binding to PRLR.
Figure 1 sAB inhibition of hPRL-R in T47D breast cancer cells.
Fluorescence microscopy images of cells treated with 100 nM cy5-hPRL (a) or cy5-hGH (b) in the presence of each sAB.
Rizk, S. S., Kouadio, J. L. K., Szymborska, A., Duguid, E. M., Mukherjee, S., Zheng, J., ... & Kossiakoff, A. A. (2015). Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling. Cell Communication and Signaling, 13(1), 1.
Figure 2 sAB inhibition of hPRL-R in T47D breast cancer cells.
Western blot detection of the time-dependent inhibition of hPRL-R signaling by hPRL-R sABs.
Rizk, S. S., Kouadio, J. L. K., Szymborska, A., Duguid, E. M., Mukherjee, S., Zheng, J., ... & Kossiakoff, A. A. (2015). Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling. Cell Communication and Signaling, 13(1), 1.
Figure 3 Crystal structure of the hPRL-R in complex with sAB A8.
Inhibition of sAB binding by hGH or PRL using phage ELISA. Both hGH (left panel) and PRL (right panel) inhibit the interaction between phage-displayed sABs and hPRL-R in a concentration dependent manner.
Rizk, S. S., Kouadio, J. L. K., Szymborska, A., Duguid, E. M., Mukherjee, S., Zheng, J., ... & Kossiakoff, A. A. (2015). Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling. Cell Communication and Signaling, 13(1), 1.
Figure 4 sAB inhibition of hPRL-R in T47D breast cancer cells.
A Stat5 phospholyration luciferase reporter assay of T47D cells in the presence or absence of hPRL and hPRL-R sABs. A sAB against bacterial maltose binding protein (MBP) was used as a negative control.
Rizk, S. S., Kouadio, J. L. K., Szymborska, A., Duguid, E. M., Mukherjee, S., Zheng, J., ... & Kossiakoff, A. A. (2015). Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling. Cell Communication and Signaling, 13(1), 1.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
PABL-198 | Mouse Anti-PRLR Recombinant Antibody (clone CBL11Q) | WB, ELISA, FuncS | Mouse IgG |
MOB-0450CT | Recombinant Mouse anti-Human PRLR Monoclonal antibody (U5) | ELISA, WB | |
HPAB-0036-CN | Human Anti-PRLR Recombinant Antibody (HPAB-0036-CN) | WB, ELISA, IHC, FC | Chimeric (mouse/human) IgG |
HPAB-0037-CN | Human Anti-PRLR Recombinant Antibody (HPAB-0037-CN) | WB, ELISA, IHC, FC | Chimeric (mouse/human) IgG |
HPAB-1600-FY | Human Anti-PRLR Recombinant Antibody (HPAB-1600-FY) | FC, Inhib | Human IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-198 | Mouse Anti-PRLR Recombinant Antibody (clone CBL11Q); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
PFBZ-179 | Mouse Anti-PRLR Recombinant Antibody (clone A8); Fab Fragment | ELISA, Neut, WB | Mouse Fab |
PSBL-676 | Mouse Anti-PRLR Recombinant Antibody (clone sAB A8); scFv Fragment | ELISA | Mouse scFv |
HPAB-1600-FY-F(E) | Human Anti-PRLR Recombinant Antibody; Fab Fragment (HPAB-1600-FY-F(E)) | FC, WB, ELISA | Human Fab |
HPAB-1601-FY-F(E) | Human Anti-PRLR Recombinant Antibody; Fab Fragment (HPAB-1601-FY-F(E)) | FC, WB, ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1064CL | Human Anti-PRLR Recombinant Antibody (TAB-1064CL) | FC | Human IgG |
TAB-1067CL | Human Anti-PRLR Recombinant Antibody (TAB-1067CL) | ELISA | Human IgG2 |
TAB-1064CL-S(P) | Human Anti-PRLR Recombinant Antibody (TAB-1064CL-S(P)); scFv Fragment | FC | Human scFv |
TAB-1067CL-S(P) | Human Anti-PRLR Recombinant Antibody; scFv Fragment (TAB-1067CL-S(P)) | ELISA | Human scFv |
TAB-1067CL-F(E) | Human Anti-PRLR Recombinant Antibody; Fab Fragment (TAB-1067CL-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1065CL | Mouse Anti-PRLR Recombinant Antibody (TAB-1065CL) | ELISA, FuncS | Mouse IgG |
TAB-1065CL-S(P) | Mouse Anti-PRLR Recombinant Antibody; scFv Fragment (TAB-1065CL-S(P)) | ELISA | Mouse scFv |
TAB-1065CL-F(E) | Mouse Anti-PRLR Recombinant Antibody; Fab Fragment (TAB-1065CL-F(E)) | ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1066CL | Human Anti-PRLR Recombinant Antibody (TAB-1066CL) | ELISA | Humanized IgG |
TAB-1066CL-S(P) | Human Anti-PRLR Recombinant Antibody; scFv Fragment (TAB-1066CL-S(P)) | ELISA | Humanized scFv |
TAB-1066CL-F(E) | Human Anti-PRLR Recombinant Antibody; Fab Fragment (TAB-1066CL-F(E)) | ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1881CQ | Recombinant Mouse Anti-PRLR Antibody (CBL154) | Neut, WB | IgG1 |
NEUT-1882CQ | Recombinant Mouse Anti-PRLR Antibody (CBL359) | Neut, WB | IgG1 |
NEUT-1883CQ | Recombinant Mouse Anti-PRLR Antibody (6G8) | Neut, WB | IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1884CQ | Recombinant Mouse Anti-PRLR Antibody (T6) | BL, FC, ICC/IF, IHC, IP, WB | IgG2a |
NEUT-1885CQ | Recombinant Mouse Anti-PRLR Antibody (U5) | BL, FC, ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB | IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2867 | Hi-Affi™ Recombinant Rabbit Anti-PRLR Monoclonal Antibody (DS2867AB) | WB, IHC-P, ICC/IF | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0029-CN-F(E) | Human Anti-PRLR Recombinant Antibody; Fab Fragment (HPAB-0029-CN-F(E)) | WB, ELISA, IHC, FC | Human Fab |
HPAB-0030-CN-F(E) | Human Anti-PRLR Recombinant Antibody; Fab Fragment (HPAB-0030-CN-F(E)) | WB, ELISA, IHC, FC | Human Fab |
HPAB-0031-CN-F(E) | Mouse Anti-PRLR Recombinant Antibody; Fab Fragment (HPAB-0031-CN-F(E)) | WB, ELISA, IHC, FC | Mouse Fab |
HPAB-0032-CN-F(E) | Mouse Anti-PRLR Recombinant Antibody; Fab Fragment (HPAB-0032-CN-F(E)) | WB, ELISA, IHC, FC | Mouse Fab |
HPAB-0033-CN-F(E) | Mouse Anti-PRLR Recombinant Antibody; Fab Fragment (HPAB-0033-CN-F(E)) | WB, ELISA, IHC, FC | Mouse Fab |
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