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Anti-PRNP Intrabody [+36GFP] (IAB-B034(G))

Recombinant anti-PRNP intrabody in fusion with +36GFP works within cells to bind PRNP, expressed in CHO cells. Anti-prion intrabodies targeted to the lumen of the endoplasmic reticulum provide a simple and effective means to inhibit the transport of PrPC to the cell surface.      

Specifications
Immunogen
human prion protein
Host
mouse
Type
scFv-(+36GFP)
Cell Penetrating Peptide
+36 GFP
GFP with a theoretical net charge of +36 (+36 GFP) penetrated several different mammalian cell lines at very low (nanomolar) concentrations. Cationic peptides and proteins have been observed to penetrate cells, and both natural and synthetic cell-penetrating peptides are widely used as delivery vehicles. However, whereas a covalent link between the cell-penetrating peptide and its cargo is typically required.
Species Reactivity
human
Applications
Formats of immunological tests: Western blot; Coimmunopricipation; Functional studies
Target
Alternative Names
PRNP; prion protein; CJD; GSS; PrP; ASCR; KURU; PRIP
Entrez Gene ID
5621
UniProt ID
P04156

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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