Recombinant Mouse Antibody (MW1) is capable of binding to PolyQ.
Figure 1 Western blot analysis of 3B5H10 and MW1 IgG binding to huntingtin exon 1 fusion proteins with variable numbers of glutamines.
Both MW1 and 3B5H10 IgGs bound to huntingtin exon 1 proteins with normal and expanded polyQ repeats, but did not bind the TRX-tag control (top panels). Equimolar loading of huntingtin exon 1 fusion proteins was verified by blotting with the N17 antibody that recognizes the first 17 residues of huntingtin (bottom panel).
Owens, G. E., New, D. M., West Jr, A. P., & Bjorkman, P. J. (2015). Anti-PolyQ antibodies recognize a short PolyQ stretch in both normal and mutant Huntingtin Exon 1. Journal of molecular biology, 427(15), 2507-2519.
Figure 2 Dot blot analysis of 3B5H10 and MW1 IgG binding to huntingtin exon 1 fusion proteins (top panels). Equimolar loading of huntingtin proteins was verified by blotting with anti-TRX (bottom panel).
Owens, G. E., New, D. M., West Jr, A. P., & Bjorkman, P. J. (2015). Anti-PolyQ antibodies recognize a short PolyQ stretch in both normal and mutant Huntingtin Exon 1. Journal of molecular biology, 427(15), 2507-2519.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
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• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-786 | Recombinant Anti-polyQ tract Antibody | ELISA, WB, Neut, FuncS | IgG |
MHH-786 | Recombinant Human Anti-polyQ tract Antibody | ELISA, IF, FuncS | IgG |
PABL-307 | Mouse Anti-PolyQ Tract Recombinant Antibody (clone 1C2) | WB, ELISA, FuncS | Mouse IgG1 |
PABC-201 | Mouse Anti-PolyQ Tract Recombinant Antibody (clone 3B5H10) | IF, WB, FuncS, WB | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-786-F(E) | Recombinant Anti-polyQ tract Antibody Fab Fragment | ELISA, IF, FuncS | Fab |
MHH-786-F(E) | Recombinant Human Anti-polyQ tract Antibody Fab Fragment | WB, ELISA, FuncS | Fab |
PFBL-307 | Mouse Anti-PolyQ Tract Recombinant Antibody (clone 1C2); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
PFBL-308 | Mouse Anti-PolyQ Tract Recombinant Antibody (clone MW1); Fab Fragment | WB, IHC, FuncS | Mouse Fab |
PSBC-201 | Mouse Anti-PolyQ Tract Recombinant Antibody (clone 3B5H10); scFv Fragment | WB | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-786-S(P) | Recombinant Anti-polyQ tract Antibody scFv Fragment | ELISA, WB, IP, FuncS | scFv |
MHH-786-S(P) | Recombinant Human Anti-polyQ tract Antibody scFv Fragment | ELISA, IP, FuncS | scFv |
PSBL-307 | Mouse Anti-PolyQ Tract Recombinant Antibody (clone 1C2); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
PSBL-308 | Mouse Anti-PolyQ Tract Recombinant Antibody (clone MW1); scFv Fragment | WB, IHC, FuncS | Mouse scFv |
PFBC-201 | Mouse Anti-PolyQ Tract Recombinant Antibody (clone 3B5H10); Fab Fragment | WB | Mouse Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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