Anti-Human SHH Recombinant Antibody (MEDI-5304) (CAT#: TAB-566CL)
Recombinant Human monoclonal antibody expressed in CHO binding to Human SHH. MEDI-5304 is the first fully human hedgehog antibody which inhibited transcription of hedgehog target genes and osteoblast differentiation of C3H10T1/2 cells. MEDI-5304 represents a potent dual hedgehog inhibitor suitable for continued development to evaluate efficacy and safety in human patients with tumors harboring elevated levels of SHH or IHH.
Specific Inquiry
Inhib
Figure 1 MEDI-5304 inhibits the growth of HT-29/MEF coimplant tumors.
HT-29 and MEFs were mixed and implanted subcutaneously into Ncr nude mice, which were dosed intraperitoneally with varying amounts of MEDI-5304, 10 mg/kg 5E1 or 10 mg/kg R347 twice weekly starting on day 11. Student t test was used to determine significance of MEDI-5304 or 5E1 treatment relative to R347 treatment on day 35.
Michaud, N. R., Wang, Y., McEachern, K. A., Jordan, J. J., Mazzola, A. M., Hernandez, A., ... & Wang, L. (2014). Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling. Molecular cancer therapeutics, 13(2), 386-398.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- Inhib
- Related Disease
- Tumors
Product Property
- Purity
- >95% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE
- Storage
- 4 °C, -20°C if preferred
Applications
- Application Notes
- This antibody has been tested for use in Inhibition. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- SHH; sonic hedgehog; TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5; sonic hedgehog protein; sonic hedgehog homolog
- Gene ID
- 6469
- UniProt ID
- Q15465
Related Resources
JAK-STAT Signaling Pathway
Pancreatic Cancer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "SHH"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-902 | Recombinant Human Anti-human SHH Antibody | WB, IHC, FuncS | IgG |
| MOB-1591MZ | Recombinant Mouse Anti-Human SHH Antibody (clone 20I7) | ICC/IF, WB, sELISA | Mouse antibody |
| HPAB-N0236-YC | Mouse Anti-SHH Recombinant Antibody (HPAB-N0236-YC) | ELISA, FC, WB, FuncS, Inhib, IF | Mouse IgG |
| FAMAB-1549CQ | Mouse Anti-SHH Recombinant Antibody (clone 5E1) | Block, WB, ELISA, IHC | Mouse IgG1 |
| ZG-085R | Mouse Anti-SHH Recombinant Antibody (ZG-085R) | WB, ELISA | Mouse IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-902-S(P) | Recombinant Human Anti-human SHH Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
| PSBL-696 | Mouse Anti-SHH Recombinant Antibody (clone 5E1); scFv Fragment | Neut | Mouse scFv |
| HPAB-N0236-YC-S(P) | Mouse Anti-SHH Recombinant Antibody; scFv Fragment (HPAB-N0236-YC-S(P)) | ELISA, FC, WB, FuncS | Mouse scFv |
| HPAB-AP788-YC-S(P) | Human Anti-SHH Recombinant Antibody (clone 1A12); scFv Fragment | ELISA, Inhib | Human scFv |
| HPAB-AP789-YC-S(P) | Human Anti-SHH Recombinant Antibody (clone 1G12); scFv Fragment | ELISA, Inhib | Human scFv |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1955CQ | Recombinant Rat Anti-Shh Antibody (6K12) | IHC, Neut, WB | IgG2 |
| NEUT-1956CQ | Recombinant Rat Anti-Shh Antibody (CBL167) | IHC, Neut, WB | IgG2 |
| NEUT-1957CQ | Recombinant Rat Anti-Shh Antibody (CBL886) | Neut, WB | IgG2a |
| NEUT-1958CQ | Recombinant Mouse Anti-SHH Antibody (171018) | IHC-FoFr, WB, IHC-Fr, Neut, ELISA, ICC/IF | IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3261 | Hi-Affi™ Recombinant Rabbit Anti-SHH Monoclonal Antibody (DS3261AB) | FC, IHC-P, IP, WB | IgG |
| MOR-4739 | Hi-Affi™ Recombinant Rabbit Anti-SHH Monoclonal Antibody (TH253DS) | WB, IF, ICC, FC | IgG |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-082CN | Human Anti-SHH Recombinant Antibody (clone 6D7) | ELISA, FC | Human IgG2 |
| NS-082CN-F(E) | Human Anti-SHH Recombinant Antibody (clone 6D7); Fab Fragment | ELISA, FC | Human Fab |
| NS-082CN-S(P) | Human Anti-SHH Recombinant Antibody (clone 6D7); scFv Fragment | ELISA, FC | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP788-YC-F(E) | Human Anti-SHH Recombinant Antibody (clone 1A12); Fab Fragment | ELISA, Inhib | Human Fab |
| HPAB-AP789-YC-F(E) | Human Anti-SHH Recombinant Antibody (clone 1G12); Fab Fragment | ELISA, Inhib | Human Fab |
| HPAB-AP790-YC-F(E) | Human Anti-SHH Recombinant Antibody (clone 1H10); Fab Fragment | ELISA, Inhib | Human Fab |
| HPAB-AP791-YC-F(E) | Human Anti-SHH Recombinant Antibody (clone 4B6); Fab Fragment | ELISA, Inhib | Human Fab |
| HPAB-AP792-YC-F(E) | Human Anti-SHH Recombinant Antibody (clone 1G1); Fab Fragment | ELISA, Inhib | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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