Products

Anti-TLR9 Intrabody [(D-Arg)9] (IAB-B043(A))

Recombinant anti-TLR9 intrabody linked to (D-Arg)9 works within cells and binds specifically to human TLR9, expressed in E. coli cells. Intracellular antibodiess expressed inside the ER block transitory protein functions by inhibiting the translocation of the protein from the ER to its subcellular destination.      

Specifications
Immunogen
human Toll-like receptor 9
Host
human
Type
scFv-(D-Arg)9
Cell Penetrating Peptide
(D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
Species Reactivity
human
Applications
Products can be used for: Fluorescence-activated cell sorting; Immunocytochemistry; Functional studies
Target
Alternative Names
TLR9; toll-like receptor 9; CD289
Entrez Gene ID
54106
UniProt ID
Q9NR96

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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