Human Anti-TNFRSF4 Recombinant Antibody (clone 12H3) (CAT#: HPAB-0005-LSX)
Chimeric antibody 12H3 specifically binds to the extracellular domain of human CD134 and is useful for cancer treatment.
Specific Inquiry
Figure 1 Binding characteristics of mouse anti-human CD134 antibodies clone ACT35, clone 12H3, and clone 20E5 on PHA-M-stimulated human CD134 expressing T lymphocytes.
FC
Figure 2 Binding of mouse anti-human CD134 antibodies clone 12H3 and clone 20E5 on PHA-M-stimulated human CD134 expressing CD4 T lymphocytes and CD8 T lymphocytes.
FC
Figure 3 Cross-competition of non-labeled mouse anti-human CD134 antibodies clone 12H3 or clone 20E5 with PE-conjugated commercial mouse anti-CD134 antibodies clone ACT35 or clone L106 on PHA-M-stimulated human CD134 expressing T lymphocytes.
FC
Figure 4 Simultaneous binding of mouse anti-human CD134 antibodies clone 12H3 or clone 20E5 with human OX40L on PHA-M-stimulated human CD134 expressing T lymphocytes.
FuncS
Figure 5 Dose effect of exposure to mouse anti-human CD134 antibodies clone 12H3 or clone 20E5, or to human OX40L on proliferation of PHA-M-stimulated human CD134 expressing T lymphocytes.
FuncS
Figure 6 Effect of combining mouse anti-human CD134 antibodies clone 12H3 with human OX40L, or mouse anti-human CD134 antibodies clone 20E5 with human OX40L on proliferation of PHA-M-stimulated human CD134 expressing T lymphocytes.
FuncS
Figure 7 Effect of exposure to mouse anti-human CD134 antibodies clone 12H3 or clone 20E5, or to human OX40L on proliferation of anti-human CD3/anti-human CD28 antibody stimulator beads-stimulated human CD134 expressing human effector T lymphocytes.
FuncS
Figure 8 Effect of exposure to mouse anti-human CD134 antibodies clone 12H3 or clone 20E5, or to human OX40L on proliferation of anti-human CD3/anti-human CD28 antibody stimulator beads-stimulated human CD134 expressing human regulatory T lymphocytes.
FuncS
Figure 9 Effect of exposure to mouse anti-human CD134 antibodies clone 12H3 or clone 20E5, or to human OX40L on human CD134 expressing human regulatory T lymphocyte-mediated suppression of human CD134 expressing human effector T lymphocyte proliferation.
Specifications
- Host Species
- Human
- Derivation
- Chimeric
- Type
- Chimeric lgG4
- Specificity
- Human TNFRSF4
- Species Reactivity
- Human
- Clone
- 12H3
- Applications
- ELISA, FC, FuncS
- Related Disease
- Lymphoma, melanoma, sarcoma, colon cancer, breast cancer, and glioma
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Flow Cytometry and Functional Assay.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone 12H3"
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1618z | Mouse Anti-TNFRSF4 Recombinant Antibody (clone 27C4) | WB, ELISA, FC, IHC, IP | Mouse IgG1, κ |
| HPAB-0017-LSX | Human Anti-TNFRSF4 Recombinant Antibody (HPAB-0017-LSX) | ELISA, FC, Block, FuncS | Humanized IgG1, κ |
| HPAB-0018-LSX | Human Anti-TNFRSF4 Recombinant Antibody (HPAB-0018-LSX) | ELISA | Human IgG |
| HPAB-0042-FY | Human Anti-TNFRSF4 Recombinant Antibody (clone 106-222) | Inhib | Humanized IgG1, κ |
| HPAB-N0398-YC | Human Anti-TNFRSF4 Recombinant Antibody (HPAB-N0398-YC) | FC, Block | Human IgG1, κ |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-633CL | Mouse Anti-TNFRSF4 Recombinant Antibody (TAB-633CL) | ELISA | Mouse IgG |
| TAB-0877CL | Mouse Anti-TNFRSF4 Recombinant Antibody (TAB-0877CL) | FC | Mouse IgG |
| TAB-0878CL | Mouse Anti-TNFRSF4 Recombinant Antibody (TAB-0878CL) | FC, Activ | Mouse IgG |
| TAB-0886CL | Anti-Human TNFRSF4 Recombinant Antibody (12H3) | FuncS, FC | |
| TAB-0887CL | Anti-Human TNFRSF4 Recombinant Antibody (20E5) | FuncS, FC |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0873CL | Human Anti-TNFRSF4 Recombinant Antibody (TAB-0873CL) | FC, Inhib | Humanized antibody |
| TAB-0876CL | Human Anti-TNFRSF4 Recombinant Antibody (TAB-0876CL) | ELISA, FuncS, FC | Humanized IgG |
| TAB-0880CL | Human Anti-TNFRSF4 Recombinant Antibody (TAB-0880CL) | FC | Humanized antibody |
| TAB-445CQ | Anti-Human TNFRSF4 Recombinant Antibody (Vonlerolizumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
| TAB-452CQ | Anti-Human TNFRSF4 Recombinant Antibody (Tavolixizumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0874CL-S(P) | Mouse Anti-TNFRSF4 Recombinant Antibody; scFv Fragment (TAB-0874CL-S(P)) | ELISA, FC | Mouse scFv |
| TAB-0879CL-S(P) | Mouse Anti-TNFRSF4 Recombinant Antibody; scFv Fragment (TAB-0879CL-S(P)) | FC | Mouse scFv |
| TAB-0874CL-F(E) | Human Anti-TNFRSF4 Recombinant Antibody; Fab Fragment (TAB-0874CL-F(E)) | ELISA, FC | Chimeric (mouse/human) Fab |
| TAB-0875CL-F(E) | Human Anti-TNFRSF4 Recombinant Antibody; Fab Fragment (TAB-0875CL-F(E)) | ELISA, FC | Chimeric (mouse/human) Fab |
| TAB-0879CL-F(E) | Human Anti-TNFRSF4 Recombinant Antibody; Fab Fragment (TAB-0879CL-F(E)) | FC | Chimeric antibody (mouse/human) |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0881CL-F(E) | Human Anti-TNFRSF4 Recombinant Antibody; Fab Fragment (TAB-0881CL-F(E)) | ELISA, FC | Human Fab |
| TAB-0882CL-F(E) | Human Anti-TNFRSF4 Recombinant Antibody; Fab Fragment (TAB-0882CL-F(E)) | ELISA, FC | Human Fab |
| TAB-0883CL-F(E) | Human Anti-TNFRSF4 Recombinant Antibody; Fab Fragment (TAB-0883CL-F(E)) | ELISA, FC | Human Fab |
| TAB-0884CL-F(E) | Human Anti-TNFRSF4 Recombinant Antibody; Fab Fragment (TAB-0884CL-F(E)) | ELISA, FC | Human Fab |
| TAB-0885CL-F(E) | Human Anti-TNFRSF4 Recombinant Antibody; Fab Fragment (TAB-0885CL-F(E)) | ELISA, FC | Human Fab |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2159CQ | Mouse Anti-Tnfrsf4 Recombinant Antibody (clone OX-40) | FC, Block, FC, IHC-Fr, IP | Mouse IgG2b, κ |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2160CQ | Rat Anti-Tnfrsf4 Recombinant Antibody (clone OX86) | FC, FuncS, IHC-Fr, Neut, WB | Rat IgG1, κ |
| NEUT-2161CQ | Mouse Anti-TNFRSF4 Recombinant Antibody (clone CBL191) | FC, IHC, Neut | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3616 | Rabbit Anti-TNFRSF4 Recombinant Antibody (clone DS3616AB) | WB | Rabbit IgG |
Agonistic Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-102LC | Human Anti-TNFRSF4 Recombinant Antibody (clone MOXR0916) | ELISA, FC, WB, RIA, FuncS | Humanized IgG1, κ |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0002-LSX-F(E) | Human Anti-TNFRSF4 Recombinant Antibody; Fab Fragment (HPAB-0002-LSX-F(E)) | ELISA, WB | Humanized Fab |
| HPAB-0003-LSX-F(E) | Human Anti-TNFRSF4 Recombinant Antibody; Fab Fragment (HPAB-0003-LSX-F(E)) | ELISA, WB | Humanized Fab |
| HPAB-0004-LSX-F(E) | Human Anti-TNFRSF4 Recombinant Antibody; Fab Fragment (HPAB-0004-LSX-F(E)) | ELISA, WB | Humanized Fab |
| HPAB-0005-LSX-F(E) | Human Anti-TNFRSF4 Recombinant Antibody (clone 12H3); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0006-LSX-F(E) | Human Anti-TNFRSF4 Recombinant Antibody (clone 20E5); Fab Fragment | ELISA | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0042-FY-S(P) | Human Anti-TNFRSF4 Recombinant Antibody (clone 106-222); scFv Fragment | Inhib | Humanized scFv |
| HPAB-3153LY-S(P) | Human Anti-TNFRSF4 Recombinant Antibody; scFv Fragment (HPAB-3153LY-S(P)) | ELISA | Human scFv |
| HPAB-3154LY-S(P) | Human Anti-TNFRSF4 Recombinant Antibody; scFv Fragment (HPAB-3154LY-S(P)) | ELISA | Human scFv |
| HPAB-3155LY-S(P) | Human Anti-TNFRSF4 Recombinant Antibody; scFv Fragment (HPAB-3155LY-S(P)) | ELISA | Human scFv |
| HPAB-3156LY-S(P) | Human Anti-TNFRSF4 Recombinant Antibody; scFv Fragment (HPAB-3156LY-S(P)) | ELISA | Human scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-445CQ | Afuco™ Anti-TNFRSF4 ADCC Recombinant Antibody (Vonlerolizumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-452CQ | Afuco™ Anti-TNFRSF4 ADCC Recombinant Antibody (Tavolixizumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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