anti-VEGFA immunotoxin Ng76 (scFv)-Luffin-β (AGTO-L043L)
This immunotoxin was achieved by conjugating/fusing the Anti-VEGFA scFv to loofah toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to melanoma cells and the toxin enters cells by receptor-mediated endocytosis. Then loofah toxin inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treatment of melanoma.
- Species Reactivity
- Molecule Class
- Toxin Description
- Loofah toxin (Luffin-β), is separated from the silk seeds into type I ribosome inactivating protein (ribosomeinactivating protein, RIP), RIP gourd. There are many types, mainly Luffin-a, Luffin-β, Luffin-Ss, Luffin-cylin, Luffin-Pl, which Luffin-β point containing 278 amino acids, the molecular weight of 30. 583KD, etc. 9.5, capable of specifically hydrolyzing eukaryotic ribosomes 28SrRNA4324 bit of adenine, so true 60s nuclear large subunit of ribosomes inactivate significantly inhibit protein synthesis, is one of the most active single-chain RIP are currently in, is of concern immunotoxin new powerful warhead small molecule recent years
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Alternative Names
- VPF; VEGF; MVCD1; VEGFA; vascular endothelial growth factor A; Melanoma; Loofah toxin; Loofah
- Entrez Gene ID
- UniProt ID
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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