Products

Anti-histone Immunocytokine, IgG (NHS76)-IL12 (ACFP-SH113)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-histone IgG to IL12. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the histone as well as the biological activity of IL12. NHS-IL12 is a fusion protein comprising two IL12 heterodimers combined to the H-chain of an NHS76 monoclonal antibody. Murine in-vivo models have shown NHS-IL12 to be safe and efficacious with a subcutaneous route of administration showing the best results. The addition of the human IgG1 moiety resulted in a longer plasma half-life of NHS-IL12 than recombinant IL12, and a selective targeting to murine tumors in vivo. This immunocytokine was designed for treating necrotic tumor.      

Specifications
Target
Histone
Molecule Class
IgG1-IL12
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
NHS76
Related Disease
Necrotic tumor
Cytokines 1
IL12
Cytokines 1 Description
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
Cytokine 1 Species
Mouse
Cytokines 2 Description
histone
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
Histones; histone HI; histone H3; histone H2B; histone H4; histone H2A

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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