Recombinant Anti-IgE × Anti-FcγRII Bispecific Antibody (Fab2) (CAT#: FAB-L054)
Recombinant Anti-IgE × Anti-FcγRII Bispecific Antibody (Fab2) is composed of the Fab of the anti-IgE monoclonal antibody and Fab of an antibody specific for FcγRII. A linker is added between the two Fab. The bispecific antibody is somewhat smaller than a whole IgG, and therefore it clears from the blood naturally at a faster rate. This BsAb can not only fail to trigger the release of histamine by IgE-sensitized cells,but also prevent specific antigen from triggering histamine release. It can be used in the treatment of allergic diseases.
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Specifications
- Target
- IgE & FcγRII
- Type
- Fab2
- Species Reactivity
- Human
- Target 1
- IgE
- Host Species 1
- Mouse
- Target 2
- FcγRII
- Host Species 2
- Mouse
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Allergic diseases
Target
- Target 1
- IgE
- Gene ID
- 3497
- UniProt ID
- P01854
- Alternative Names
- IGHE; immunoglobulin heavy constant epsilon; IgE
- Target 2
- FcγRII
- Gene ID
- 2212
- UniProt ID
- P12318
- Alternative Names
- FCGR2A; Fc fragment of IgG, low affinity IIa, receptor (CD32); CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1; low affinity immunoglobulin gamma Fc region receptor II-a; fcRII-a; fc-gamma-RIIa; fc-gamma RII-a; igG Fc receptor II-a; Immunoglobulin G Fc receptor II
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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