Products

Ibritumomab tiuxetan (TP-106CL)

Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light chains of 213 amino acids each.      

Specifications
Classify
Protein therapeutics that deliver other compounds or proteins
Therapeutic
Ibritumomab tiuxetan
Trade Name
Zevalin
Function
A mAb portion that recognizes CD20+ B cells and induces apoptosis while the chelation site allows either imaging (In-111) or cellular damage by beta emission (Y-90)
Examples of Clinical Use
Relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma (NHL), including rituximab-refractory follicular NHL
References
Synonyms
Ibritumomab, mAb Murine (IGG1) Anti P19437 (CD20_MOUSE)
UniProt
P01865
Genbank
J00470

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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