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PE-A*01:01/Human PDHA1 (KSDPIMLLK) MHC Tetramer (CAT#: MHC-LC4342)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human PDHA1 of peptide KSDPIMLLK covering 13-21 and A*01:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.


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Specific Inquiry
  • Size:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line HeLa
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47864/1645_G11_19_cr57b568f223f4d_selected.jpg
Normal Tissue
Figure 2 Heart muscle
Figure 2 Heart muscle
(Cardiomyocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47864/113115_B_5_6.jpg
Figure 3 Lymph node
Figure 3 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47487/113196_A_9_8.jpg
Figure 4 Colon
Figure 4 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47864/113115_A_8_3.jpg
Figure 5 Kidney
Figure 5 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47864/113115_A_8_5.jpg
Figure 6 Testis
Figure 6 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47864/113115_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000131828-PDHA1

Specifications

  • Allele
  • A*01:01
  • Class
  • Class I
  • Antigen
  • PDHA1
  • Antigen Species
  • Human
  • Peptide
  • KSDPIMLLK
  • Range
  • 13-21
  • Conjugate
  • PE
  • Application
  • FCM

Target

  • Antigen Introduction
  • The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • PDHA1; pyruvate dehydrogenase alpha 1; PDHA; PDHAD; PHE1A; PDHCE1A

Downloads

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MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC4343 PE-A*03:01/Human PDHA1 (KSDPIMLLK) MHC Tetramer FCM
MHC-LC4344 PE-A*11:01/Human PDHA1 (KSDPIMLLK) MHC Tetramer FCM
MHC-LC4345 PE-A*69:01/Human PDHA1 (KSDPIMLLK) MHC Tetramer FCM

Recombinant Antibody

CAT Product Name Application Type
VS4-CJ70 Recombinant Mouse Anti-PDHA1 Antibody (VS4-CJ70) ELISA, WB, ICC Mouse IgG1
VS3-FY1115 Recombinant Mouse Anti-PDHA1 Antibody (clone 1G10C10) ELISA, WB, IP, IHC, ICC, FC Mouse IgG1
VS3-FY1116 Recombinant Mouse Anti-PDHA1 Antibody (clone 2A2H7) ELISA, WB, FC Mouse IgG2b
VS3-FY1117 Recombinant Mouse Anti-PDHA1 Antibody (clone 4E12D6) ELISA, WB, IHC, ICC, FC Mouse IgG2a
VS3-FY1118 Recombinant Rabbit Anti-PDHA1 Antibody (clone R06-1J4) WB, ICC, IF, IP Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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