Anti-Human RHD Recombinant Antibody (Roledumab) (CAT#: TAB-460CQ)
Recombinant monoclonal antibody to RHD. Roledumab is a human monoclonal antibody that can be potentially used in the treatment of Haemolytic disease of newborn.
Specific Inquiry
Figure 1 Time–course of the serum concentrations of roledumab after intravenous administration of different doses.
Open circles: 3000 ug; open squares: 1000 ug; filled circles: 300 ug; filled squares: 100 ug.
Yver, A., Homery, M. C., Fuseau, E., Guemas, E., Dhainaut, F., Quagliaroli, D., ... & Prost, J. F. (2012). Pharmacokinetics and safety of roledumab, a novel human recombinant monoclonal anti‐RhD antibody with an optimized Fc for improved engagement of FCγRIII, in healthy volunteers. Vox sanguinis, 103(3), 213-222.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1, κ
- Specificity
- Human RHD
- Species Reactivity
- Human
- Applications
- ELISA, IHC, FC, IP, IF, Inhib
- Conjugate
- Unconjugated
- Trade name
- Dmatria
- CAS
- 1174008-79-7
- Generic Name
- Roledumab
- UNII
- Z4T52O86QV
- Related Disease
- Haemolytic disease of newborn
Product Property
- Purity
- > 95% as determined by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The RHD antibody has been reported in applications of PK.
Target
- Alternative Names
- RHD; Rh blood group, D antigen; RH; Rh4; RH30; RhII; RhPI; DIIIc; RHCED; RHDel; RHPII; RhDCw; CD240D; RHXIII; RHDVA(TT); RhK562-II; blood group Rh(D) polypeptide; D antigen (DCS); RH polypeptide 2; rhesus D antigen; blood group antigen D; Rh blood group, D anitgen; Rhesus system D polypeptide; Rh blood group antigen Evans; Rhesus blood group D antigen allele DIII type 7
- Gene ID
- 6007
- UniProt ID
- B4DLT8
Related Resources
Please refer to Roledumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Roledumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Roledumab"
Afuco™ Anti-RHD ADCC Recombinant Antibody (Roledumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to RHD. Roledumab is a human monoclonal antibody that can be potentially used in the treatment of Haemolytic disease of newborn.
See other products for "RHD"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1485z | Mouse Anti-RHD Recombinant Antibody (clone 26D5) | WB, IP, IF, FC | Mouse IgG1 |
| FAMAB-0043JF | Human Anti-RHD Recombinant Antibody (clone MD10) | WB, ELISA | Human IgG1, λ |
| FAMAB-0045JF | Human Anti-RHD Recombinant Antibody (clone MD11) | WB, ELISA, FuncS | Human IgG, λ |
| FAMAB-0046JF | Human Anti-RHD Recombinant Antibody (clone MD04) | WB, ELISA, FuncS | Human IgG3, κ |
| HPAB-1547WJ | Human Anti-RHD Recombinant Antibody (clone SH04) | ELISA, WB | Human IgG1, κ |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-321CT | Anti-Human Rhesus D Recombinant Antibody (F60) | ELISA | Human antibody |
| TAB-322CT | Anti-Human Rhesus D Recombinant Antibody (D31) | ELISA | Human antibody |
| TAB-323CT | Anti-Human Rhesus D Recombinant Antibody (DF5) | ELISA | Human antibody |
| TAB-324CT | Human Anti-RHD Recombinant Antibody (TAB-324CT) | ELISA, FC | Human IgG1, λ |
| TAB-325CT | Human Anti-RHD Recombinant Antibody (TAB-325CT) | ELISA, FC | Human IgG1, λ |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-080LC | Recombinant Anti-Human RHD Antibody (Fc glycosylation) | ELISA | Human antibody |
| Gly-081LC | Recombinant Anti-Human RHD Antibody (Fc glycosylation) | ELISA | Human antibody |
| Gly-082LC | Recombinant Anti-Human RHD Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
| Gly-114LC | Recombinant Anti-Human RHD Antibody (Fc glycosylation) | ELISA | Human antibody |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-243 | Afuco™ Anti-RHD ADCC Recombinant Antibody (Morolimumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-460CQ | Afuco™ Anti-RHD ADCC Recombinant Antibody (Roledumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| AFC-TAB-149 | Afuco™ Anti-RHD ADCC Recombinant Antibody (Atorolimumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0043JF-F(E) | Human Anti-RHD Recombinant Antibody (clone MD10); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| FAMAB-0044JF-F(E) | Human Anti-RHD Recombinant Antibody (clone MD02); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| FAMAB-0045JF-F(E) | Human Anti-RHD Recombinant Antibody (clone MD11); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| FAMAB-0046JF-F(E) | Human Anti-RHD Recombinant Antibody (clone MD04); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| HPAB-1547WJ-F(E) | Human Anti-RHD Recombinant Antibody; Fab Fragment (clone SH04) | ELISA, WB | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0045JF-S(P) | Human Anti-RHD Recombinant Antibody (clone MD11); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| FAMAB-0046JF-S(P) | Human Anti-RHD Recombinant Antibody (clone MD04); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| HPAB-1547WJ-S(P) | Human Anti-RHD Recombinant Antibody; scFv Fragment (clone SH04) | ELISA, WB | Human scFv |
| HPAB-1548WJ-S(P) | Human Anti-RHD Recombinant Antibody; scFv Fragment (clone SH08) | ELISA, WB | Human scFv |
| HPAB-1549WJ-S(P) | Human Anti-RHD Recombinant Antibody; scFv Fragment (clone SH12) | ELISA, WB | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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