This HER3 specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities (KD=0.7 nM) for HER3 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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CAT | Product Name | Application | Type |
---|---|---|---|
NAB-1729-sdAb | Recombinant Anti-human ERBB3 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
TAB-070CT | Llama Anti-ERBB3 Recombinant Single Domain Antibody (TAB-070CT) | FC, Block | Llama VHH |
PABC-556 | Recombinant Llama Anti-ERBB3 Single Domain Antibody (PABC-556) | ELISA, SPR | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1319z | Mouse Anti-ERBB3 Recombinant Antibody (clone 22C5) | ELISA, ICC, IF, WB | Mouse IgG1 |
PABL-127 | Human Anti-ERBB3 Recombinant Antibody (PABL-127) | ELISA, WB, FuncS | Human IgG |
PABL-128 | Mouse Anti-ERBB3 Recombinant Antibody (PABL-128) | WB, Block, FuncS | Mouse IgG |
HPAB-0081-FY | Human Anti-ERBB3 Recombinant Antibody (HPAB-0081-FY) | Inhib, FuncS | Humanized IgG1, κ |
HPAB-0120-FY | Human Anti-ERBB3 Recombinant Antibody (HPAB-0120-FY) | ELISA, WB | Humanized IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-189 | Human Anti-ERBB3 Recombinant Antibody (TAB-189) | IP, IF, FuncS, FC, Neut, ELISA, ICC | Human IgG1, κ |
TAB-065CT | Human Anti-ERBB3 Recombinant Antibody (TAB-065CT) | ELISA, FC | Human IgG1 |
TAB-066CT | Human Anti-ERBB3 Recombinant Antibody (TAB-066CT) | ELISA, Inhibion, FC | Human IgG |
TAB-065CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-065CT-F(E)) | ELISA, FC | Human Fab |
TAB-066CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-066CT-F(E)) | ELISA, Inhibion, FC | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-892 | Anti-Human ERBB3/ErbB 3 Recombinant Antibody (Seribantumab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG2 - lambda |
TAB-H22 | Anti-Human ERBB3 Recombinant Antibody (Duligotuzumab) (TAB-H22) | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 - kappa |
TAB-057CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-057CT-S(P)) | Inhibion, ELISA | Humanized scFv |
TAB-058CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-058CT-S(P)) | WB, ELISA, Inhib | Human scFv |
TAB-063CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-063CT-S(P)) | ELISA, Inhib, FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L074E | HRGβ2-PE immunotoxin | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0508CL | Anti-Human ERBB3 Recombinant Antibody (1A5) | ELISA, FC, Inhib, FuncS | |
TAB-0509CL | Anti-Human ERBB3 Recombinant Antibody (3D4) | Inhib, FC | |
TAB-0552CL | Mouse Anti-ERBB3 Recombinant Antibody (TAB-0552CL) | ELISA, Inhib | Mouse IgG |
TAB-0553CL | Mouse Anti-ERBB3 Recombinant Antibody (TAB-0553CL) | ELISA, Inhib | Mouse IgG |
TAB-060CT | Rabbit Anti-ERBB3 Recombinant Antibody (TAB-060CT) | Inhib, ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-061CT | Human Anti-ERBB3 Recombinant Antibody (TAB-061CT) | Inhib, ELISA | Chimeric (Rabbit/Human) antibody |
TAB-061CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-061CT-S(P)) | Inhib, ELISA | Human scFv |
TAB-061CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-061CT-F(E)) | Inhib, ELISA | Chimeric (Rabbit/Human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-738CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone CBL932) | Neut, IP | Mouse IgG1 |
NEUT-739CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone CBL483) | FC, CyTOF®, ELISA, Neut | Mouse IgG1 |
NEUT-740CQ | Human Anti-ERBB3 Recombinant Antibody (clone CBL1019) | Neut | Human IgG1, κ |
NEUT-741CQ | Human Anti-ERBB3 Recombinant Antibody (clone CBL1020) | Neut | Human IgG1, κ |
NEUT-742CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone M908) | Neut | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1179 | Hi-Affi™ Rabbit Anti-ERBB3 Recombinant Antibody (clone DS1179AB) | ICC, IF, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0286-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 1153); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
HPAB-0725LY-F(E) | Human Anti-ERBB3 Recombinant Antibody (clone CBL015); Fab Fragment | ELISA, Inhib | Humanized Fab |
HPAB-2323LY-F(E) | Human Anti-ERBB3 Recombinant Antibody (clone A); Fab Fragment | ELISA, RIA | Human Fab |
HPAB-0171-WJ-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-0171-WJ-F(E)) | ELISA | Human Fab |
HPAB-0200-WJ-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 205.10.1); Fab Fragment | ELISA, WB | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-H21 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-422CQ | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Elgemtumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, BL | ADCC enhanced antibody |
AFC-TAB-189 | Afuco™ Anti-ERBB3 Recombinant Antibody (AFC-TAB-189), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | Human IgG1, κ |
AFC-TAB-H22 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotuzumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
AFC-TAB-892 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Seribantumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0436-FY-S(P) | Mouse Anti-ERBB3 Recombinant Antibody (clone 15D5); scFv Fragment | Inhib | Mouse scFv |
HPAB-0437-FY-S(P) | Mouse Anti-ERBB3 Recombinant Antibody (clone 1D9); scFv Fragment | Inhib | Humanized scFv |
HPAB-0438-FY-S(P) | Mouse Anti-ERBB3 Recombinant Antibody (clone 993); scFv Fragment | FC, Inhib | Mouse scFv |
FAMAB-0047JF-S(P) | Human Anti-ERBB3 Recombinant Antibody (clone PM6); scFv Fragment | WB, ELISA, FuncS | Human scFv |
PSBS-0069 | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (PSBS-0069) | ELISA, Block, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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