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A*02:01/Human Cyclin-dependent kinase inhibitor 1 (FAWERVRGL) MHC Pentamer (CAT#: MHC-YF387)

MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed Cyclin-dependent kinase inhibitor 1-derived peptide of FAWERVRGL sequence covering 97-105 and A*02:01 molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.


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  • Gene Expression
  • Datasheet
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Subcellular Location
Figure 1 IF staining of human cell line RT4
Figure 1 IF staining of human cell line RT4
(Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5946/1541_C12_6_selected.jpg
Normal Tissue
Figure 2 IHC staining of human cervix, uterine
Figure 2 IHC staining of human cervix, uterine
(Immunohistochemical staining of human cervix, uterine shows nuclear positivity in squamous cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64/156817_B_8_3_selected.jpg
Figure 3 IHC staining of human urinary bladder
Figure 3 IHC staining of human urinary bladder
(Immunohistochemical staining of human urinary bladder shows strong nuclear positivity in urothelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69401/155899_A_6_5_selected.jpg
Figure 4 Colon
Figure 4 Colon
(Glandular cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64/159107_A_7_3.jpg
Figure 5 Pancreas
Figure 5 Pancreas
(Pancreatic endocrine cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64/159107_A_1_3.jpg
Figure 6 Testis
Figure 6 Testis
(Leydig cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64/159107_A_5_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HHSteC, HSkMC, hTCEpi, LHCN-M2)
Figure 7 RNA cell line category: Cell line enhanced (HHSteC, HSkMC, hTCEpi, LHCN-M2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000124762-CDKN1A

Specifications

  • Allele
  • A*02:01
  • Class
  • Class I
  • Antigen
  • Cyclin-dependent kinase inhibitor 1
  • Antigen Species
  • Human
  • Peptide
  • FAWERVRGL
  • Range
  • 97-105
  • Conjugate
  • Unlabeled, Biotin, R-PE, APC
  • Application
  • FCM

Target

  • Antigen Introduction
  • Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
  • Alternative Names
  • Cyclin Dependent Kinase Inhibitor 1A; Cyclin-Dependent Kinase Inhibitor 1A (P21, Cip1); CDK-Interacting Protein 1; CDKN1; CAP20; MDA-6; CIP1; SDI1; WAF1; P21;

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Recombinant Antibody

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MOB-2113MZ Recombinant Mouse Anti-Human CDKN1A Antibody (clone FB20) FC, ICC, IHC-Fr, IHC-P, IP, WB Mouse antibody
ZG-1114F Mouse Anti-CDKN1A Recombinant Antibody (clone WA1) FC, ICC, IHC-Fr, IHC-P, WB, ELISA Mouse IgG1
VS3-WK744 Mouse Anti-CDKN1A Recombinant Antibody (clone Mix-mA) WB Mouse IgG1

Fab Fragment Antibody

CAT Product Name Application Type
MOB-190-F(E) Recombinant Anti-human CDKN1A Antibody Fab Fragment FC, Neut, Funcs Fab
MHH-190-F(E) Recombinant Human Anti-human CDKN1A Antibody Fab Fragment RIA, IF, FuncS Fab

scFv Fragment Antibody

CAT Product Name Application Type
MOB-190-S(P) Recombinant Anti-human CDKN1A Antibody scFv Fragment IF, FC, Biosensors, FuncS scFv
MHH-190-S(P) Recombinant Human Anti-human CDKN1A Antibody scFv Fragment WB, IF, FuncS scFv

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0114MZ Chicken Anti-CDKN1A Polyclonal IgY WB Chicken antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0639 Hi-Affi™ Rabbit Anti-CDKN1A Recombinant Antibody (clone DS639AB) ICC, IHC-P, IP, WB Rabbit IgG
MOR-4658 Hi-Affi™ Rabbit Anti-CDKN1A Recombinant Antibody (clone TH172DS) WB, IF, ICC, FC Rabbit IgG
MOR-0073-FY Rabbit Anti-CDKN1A Recombinant Antibody (clone AFY0044) ICC, IHC-P, WB Rabbit IgG

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-YF386 A*02:01/Human Cyclin-dependent kinase 4 (ALTPVVVTL) MHC Pentamer FCM

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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