This product is a Human antibody that recognizes Aβ42.
Figure 1 Dot Blot analysis of Aβ42 monomers, oligomers, protofibrils, and fibrils (10 μM each, 10 μL each) probed with B4 and scFv HT7.
Zhang, Y., Huai, Y., Zhang, X., Song, C., Cai, J., & Zhang, Y. (2019). The mode of action of an anti-oligomeric amyloid β-protein antibody affects its protective efficacy. Neurotoxicity Research, 35, 304-317.
Figure 2 Western Blot analysis of various Aβ42 species, ranging from Aβ42 monomers to fibrils, probed with scFv HT7, and the mixture of the four Aβ42 species was probed with B4 antibody (positive control).
Zhang, Y., Huai, Y., Zhang, X., Song, C., Cai, J., & Zhang, Y. (2019). The mode of action of an anti-oligomeric amyloid β-protein antibody affects its protective efficacy. Neurotoxicity Research, 35, 304-317.
Figure 3 Effects of scFv HT7 on Aβ42-induced cytotoxicity as estimated by MTT cell viability.
Zhang, Y., Huai, Y., Zhang, X., Song, C., Cai, J., & Zhang, Y. (2019). The mode of action of an anti-oligomeric amyloid β-protein antibody affects its protective efficacy. Neurotoxicity Research, 35, 304-317.
Figure 4 Neutralization and inhibition of Aβ42-induced cytotoxicity by scFv HT7 were compared by MTT assay.
Zhang, Y., Huai, Y., Zhang, X., Song, C., Cai, J., & Zhang, Y. (2019). The mode of action of an anti-oligomeric amyloid β-protein antibody affects its protective efficacy. Neurotoxicity Research, 35, 304-317.
Figure 5 SH-SY5Y cell profiles in the presence of Aβ42 oligomers or Aβ42 oligomers plus scFv HT7.
Zhang, Y., Huai, Y., Zhang, X., Song, C., Cai, J., & Zhang, Y. (2019). The mode of action of an anti-oligomeric amyloid β-protein antibody affects its protective efficacy. Neurotoxicity Research, 35, 304-317.
Figure 6 Robust somatodendritic tau accumulation was detected in the brains of 3xTg-AD mice at 6, 12, and 18 months of age using the human specific tau antibody HT7.
Oddo, S., Caccamo, A., Tseng, B., Cheng, D., Vasilevko, V., Cribbs, D. H., & LaFerla, F. M. (2008). Blocking Aβ42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Aβ and tau pathology. Journal of Neuroscience, 28(47), 12163-12175.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-25 | Recombinant Anti-human Aβ42 Antibody | WB, FC, FuncS | IgG |
MHH-25 | Recombinant Human Anti-human Aβ42 Antibody | FC, WB, FuncS | IgG |
FAMAB-0160-CN | Human Anti-Aβ42 Recombinant Antibody (clone scFv59) | WB, ELISA, IF, IHC | Human IgG |
HPAB-0511-WJ | Mouse Anti-Aβ42 Recombinant Antibody (clone 3F5) | Inhib, ELISA, Live cell imaging, FuncS | Mouse IgG2b |
HPAB-2064-FY | Human Anti-Aβ42 Recombinant Antibody (clone 8F5) | Neut, ELISA, DB, IF | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-25-F(E) | Recombinant Anti-human Aβ42 Antibody Fab Fragment | Neut, IF, FuncS | Fab |
MHH-25-F(E) | Recombinant Human Anti-human Aβ42 Antibody Fab Fragment | IF, FC, Biosensors, FuncS | Fab |
FAMAB-0160-CN-F(E) | Human Anti-Aβ42 Recombinant Antibody (clone scFv59); Fab Fragment | WB, ELISA, IF, IHC | Human Fab |
HPAB-0511-WJ-F(E) | Mouse Anti-Aβ42 Recombinant Antibody (clone 3F5); Fab Fragment | ELISA, FC | Mouse Fab |
HPAB-2064-FY-F(E) | Human Anti-Aβ42 Recombinant Antibody (clone 8F5); Fab Fragment | Neut, ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-25-S(P) | Recombinant Anti-human Aβ42 Antibody scFv Fragment | WB, FC, FuncS | scFv |
MHH-25-S(P) | Recombinant Human Anti-human Aβ42 Antibody scFv Fragment | Neut, WB, FuncS | scFv |
FAMAB-0160-CN-S(P) | Human Anti-Aβ42 Recombinant Antibody (clone scFv59); scFv Fragment | WB, ELISA, IF, IHC | Human scFv |
HPAB-0511-WJ-S(P) | Mouse Anti-Aβ42 Recombinant Antibody (clone 3F5); scFv Fragment | ELISA, FC | Mouse scFv |
HPAB-2064-FY-S(P) | Human Anti-Aβ42 Recombinant Antibody (clone 8F5); scFv Fragment | Neut, ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
IAB-B042(A) | Recombinant Anti-human Aβ42 Intrabody [(D-Arg)9] | CO-IP, FuncS | scFv-(D-Arg)9 |
IAB-B042(G) | Recombinant Anti-human Aβ42 Intrabody [+36 GFP] | ELISA, IF, Neut, FuncS | scFv-(+36GFP) |
IAB-B042(T) | Recombinant Anti-human Aβ42 Intrabody [Tat] | ELISA, Neut, FuncS | scFv-Tat |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-2023-FY-VHH | Camelid Anti-Aβ42 Recombinant Single Domain Antibody (HPAB-2023-FY-VHH) | ELISA | Llama VHH |
HPAB-2024-FY-VHH | Camelid Anti-Aβ42 Recombinant Single Domain Antibody (HPAB-2024-FY-VHH) | ELISA | Llama VHH |
HPAB-2025-FY-VHH | Camelid Anti-Aβ42 Recombinant Single Domain Antibody (HPAB-2025-FY-VHH) | ELISA | Llama VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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