Rabbit Anti-ACVR2B Recombinant Antibody (clone R01-2I1) (CAT#: VS3-FY1964)

• Immunogen
• Human activin receptor type IIB/ACVR2B synthetic peptide

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse, Rat, Hamster ACVR2B

• Species Reactivity
• Human, Mouse, Rat, Hamster

• Clone
• R01-2I1

• Applications
• Western Blot

• MW
• The calculated weight of the target protein is approximately 58 kDa, while the observed molecular weight stands at 58 kDa.

• Related Disease
• Musculoskeletal; Connective Tissue Diseases (Miscellaneous)

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA

• Preservative
• 0.01% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000

• Alternative Names
• Activin A Receptor Type 2B; Activin A Receptor, Type IIB; EC 2.7.11.30; ActR-IIB; Activin Receptor Type IIB; Activin Receptor Type-2B; EC 2.7.11; ACTRIIB; HTX4

• Gene ID
• 93

• UniProt ID
• Q13705

• Sequence Similarities
• Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

• Cellular Localization
• Cell membrane, Membrane

• Post Translation Modifications
• Phosphorylated.
  Constitutive phosphorylation is in part catalyzed by its own kinase activity.
  (Q13705-AVR2B_HUMAN)
  Glycosylation at Asn42 and Asn65 (NX_Q13705 [NX_Q13705-1])
  Modification sites at PhosphoSitePlus (Q13705)
  Glycosylation from GlyGen (Q13705) 2 sites

• Protein Refseq
• XP_005265640.1; XP_016863003.1; XP_016863004.1; XP_016863005.1; NP_001097.2

• Function
• Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody