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  • Rabbit Anti-AHCY Recombinant Antibody (clone R35-5L-9)

Rabbit Anti-AHCY Recombinant Antibody (clone R35-5L-9) (CAT#: VS3-FY2133)

The anti-AHCY antibody is a rabbit recombinant monoclonal antibody that binds to human AHCY protein, a calculated weight of 48 kDa. It cross-reacts with mouse, rat.
The following recommendations serve as a starting point for assay optimization. The actual working concentration may vary and should be determined by the user. The R35-5L-9 is recommended for detection of target protein by western blotting (dilution range 1:500-1:1000).


See more Engineered Antibody products for AHCY
Specific Inquiry
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  • Datasheet
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  • COA
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Figure 1 IF staining of human cell line CACO-2
(Immunofluorescent staining of human cell line CACO-2 shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/44675/if_selected.jpg
Normal Tissue
Figure 2 Lymph node
Figure 2 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41225/87881_A_8_8.jpg
Figure 3 Cerebral cortex
Figure 3 Cerebral cortex
(Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41225/87881_B_9_5.jpg
Figure 4 Colon
Figure 4 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41225/87881_A_7_3.jpg
Figure 5 Liver
Figure 5 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Nuclear Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41225/87881_A_7_4.jpg
Figure 6 Kidney
Figure 6 Kidney
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41225/87881_A_9_5.jpg
Figure 7 Testis
Figure 7 Testis
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41225/87881_A_6_6.jpg
Figure 8 Skin
Figure 8 Skin
(Fibroblasts Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Keratinocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Langerhans Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Melanocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41225/87881_B_7_1.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Figure 9 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000101444-AHCY

Specifications

  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human, Mouse and Rat AHCY
  • Species Reactivity
  • Human, Mouse, Rat
  • Clone
  • R35-5L-9
  • Applications
  • Western Blot
  • Conjugate
  • Unconjugated
  • MW
  • The calculated weight of the target protein is approximately 48 kDa, while the observed molecular weight stands at 47kDa.
  • Related Disease
  • Hypermethioninemia With S-Adenosylhomocysteine Hydrolase Deficiency and S-Adenosylhomocysteine Hydrolase Deficiency

Product Property

  • Format
  • Liquid
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS (pH 7.4), 150 mM NaCl, 50% glycerol
  • Preservative
  • 0.02% Sodium azide
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • Western Blot: 1/500-1/1000

Target

  • Alternative Names
  • Adenosylhomocysteinase; S-Adenosyl-L-Homocysteine Hydrolase; S-Adenosylhomocysteine Hydrolase; EC 3.3.1.1; AdoHcyase; SAHH
  • Sequence Similarities
  • Belongs to the adenosylhomocysteinase family.
  • Cellular Localization
  • Cytoplasm, Endoplasmic reticulum, Nucleus
  • Post Translation Modifications
  • Ubiquitination at Lys8, Lys20, Lys166, Lys188, Lys226, and Lys412 (NX_P23526 [NX_P23526-1])
    Modification sites at PhosphoSitePlus (P23526)
    Glycosylation from GlyGen (P23526) 2 sites, 1 O-linked glycan (2 sites)
  • Function
  • Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine.
    Binds copper ions (By similarity).

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "AHCY"

Recombinant Antibody

CAT Product Name Application Type
MOB-1056CT Mouse Anti-AHCY Recombinant Antibody (clone EML125) ELISA, WB Mouse IgM
VS4-WK23 Rabbit Anti-AHCY Recombinant Antibody (clone 13H8) ELISA, WB Rabbit IgG

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0107 Hi-Affi™ Rabbit Anti-AHCY Recombinant Antibody (clone DS107AB) WB Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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