Mouse Anti-Angiotensin II Recombinant Antibody (clone KAA8) (CAT#: HPAB-0068-YJ)

This product is a recombinant mouse antibody that recognizes mammal Angiotensin II. Mab KAA8 exhibits limited cross-reactivity with Angiotensin III when evaluated in a radio¬immunoassay for Angiotensin II. Mab KAA8 inhibits Angiotensin II's biological actions by interfering with its ability to interact with its physiological receptor. It is useful in alleviating angiotensin II-induced hypertension and in the treatment of congestive heart failure.


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  • Published Data
  • Datasheet
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Inhib

Figure 1 Line graphs showing effects of vehicle (1 ml/kg i. v., n = 7) and KAA8 (5 and 50 mg/kg i.v., n=7 and 5, respectively) on mean blood pressure, cardiac output, total peripheral resistance, and heart rate responses to spinal cord stimulation in pithed rats

Figure 1 Line graphs showing effects of vehicle (1 ml/kg i. v., n = 7) and KAA8 (5 and 50 mg/kg i.v., n=7 and 5, respectively) on mean blood pressure, cardiac output, total peripheral resistance, and heart rate responses to spinal cord stimulation in pithed rats

Wong, P. C., Reilly, T. M., & Timmermans, P. B. (1989). Effect of a monoclonal antibody to angiotensin II on hemodynamic responses to noradrenergic stimulation in pithed rats. Hypertension, 14(5), 488-497.

Inhib

Figure 2 Line graphs showing effects of vehicle (1 ml/kg i.v., n=5J andKAA8 (5 and50 mg/kgi.v., n=6and5, respectively) on mean blood pressure, cardiac output, total peripheral resistance, and heart rate responses tonorepinephrine (NE) in pithed rats.

Figure 2 Line graphs showing effects of vehicle (1 ml/kg i.v., n=5J andKAA8 (5 and50 mg/kgi.v., n=6and5, respectively) on mean blood pressure, cardiac output, total peripheral resistance, and heart rate responses tonorepinephrine (NE) in pithed rats.

Wong, P. C., Reilly, T. M., & Timmermans, P. B. (1989). Effect of a monoclonal antibody to angiotensin II on hemodynamic responses to noradrenergic stimulation in pithed rats. Hypertension, 14(5), 488-497.


Specifications

  • Immunogen
  • Angiotensin II coupled to keyhole limpet hemocyanin (KLH)
  • Host Species
  • Mouse
  • Type
  • Mouse IgG
  • Specificity
  • Human
  • Species Reactivity
  • Mammal
  • Clone
  • KAA8
  • Applications
  • Inhib, RIA, ELISA
  • Related Disease
  • Hypertension

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • The antibody KAA8 has been reported in applications of Inhibition, Radioimmunoassay, Enzyme-linked Immunosorbent Assay. It's recommended that the optimal antibody concentration, dilution, incubition time etc. be carefully titrated in specific assays. inhibition:KAA8 5 and 50 mg/kg

Target

  • Alternative Names
  • Angiotensin II; KAA8

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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