This product is a recombinant mouse antibody that recognizes mammal Angiotensin II. Mab KAA8 exhibits limited cross-reactivity with Angiotensin III when evaluated in a radio¬immunoassay for Angiotensin II. Mab KAA8 inhibits Angiotensin II's biological actions by interfering with its ability to interact with its physiological receptor. It is useful in alleviating angiotensin II-induced hypertension and in the treatment of congestive heart failure.
Figure 1 Line graphs showing effects of vehicle (1 ml/kg i. v., n = 7) and KAA8 (5 and 50 mg/kg i.v., n=7 and 5, respectively) on mean blood pressure, cardiac output, total peripheral resistance, and heart rate responses to spinal cord stimulation in pithed rats
Wong, P. C., Reilly, T. M., & Timmermans, P. B. (1989). Effect of a monoclonal antibody to angiotensin II on hemodynamic responses to noradrenergic stimulation in pithed rats. Hypertension, 14(5), 488-497.
Figure 2 Line graphs showing effects of vehicle (1 ml/kg i.v., n=5J andKAA8 (5 and50 mg/kgi.v., n=6and5, respectively) on mean blood pressure, cardiac output, total peripheral resistance, and heart rate responses tonorepinephrine (NE) in pithed rats.
Wong, P. C., Reilly, T. M., & Timmermans, P. B. (1989). Effect of a monoclonal antibody to angiotensin II on hemodynamic responses to noradrenergic stimulation in pithed rats. Hypertension, 14(5), 488-497.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-65 | Recombinant Anti-Angiotensin II Antibody | ELISA, WB, FuncS | IgG |
MHH-65 | Recombinant Human Anti-Angiotensin II Antibody | WB, IP, FuncS | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-65-F(E) | Recombinant Anti-Angiotensin II Antibody Fab Fragment | WB, FuncS | Fab |
MHH-65-F(E) | Recombinant Human Anti-Angiotensin II Antibody Fab Fragment | RIA, ELISA, FuncS | Fab |
HPAB-0068-YJ-F(E) | Mouse Anti-Angiotensin II Recombinant Antibody (clone KAA8); Fab Fragment | Neut, RIA, ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-65-S(P) | Recombinant Anti-Angiotensin II Antibody scFv Fragment | ELISA, IF, FuncS | scFv |
MHH-65-S(P) | Recombinant Human Anti-Angiotensin II Antibody scFv Fragment | WB, Neut, FuncS | scFv |
HPAB-0068-YJ-S(P) | Mouse Anti-Angiotensin II Recombinant Antibody (clone KAA8); scFv Fragment | Neut, RIA, ELISA | Mouse scFv |
There are currently no Customer reviews or questions for HPAB-0068-YJ. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.