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Mouse Anti-CBX3 Recombinant Antibody (VS3-CJ81) (CAT#: VS3-CJ81)

This product is a mouse antibody that recognizes CBX3.


See more Engineered Antibody products for CBX3
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  • Gene Expression
  • Datasheet
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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & nuclear bodies.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4902/85_C1_1_selected.jpg
Figure 2 IHC staining of human colon
Figure 2 IHC staining of human colon
(Immunohistochemical staining of human colon shows distinct nuclear positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4902/ihc_selected.jpg
Figure 3 IHC staining of human placenta
Figure 3 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows strong nuclear positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1973/ihc_selected.jpg
Figure 4 IF staining of human cell line A-431
Figure 4 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4902/108_C1_1_red_green.jpg
Figure 5 IF staining of human cell line U-2 OS
Figure 5 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & nuclear bodies.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4902/87_C1_1_red_green.jpg
Normal Tissue
Figure 6 Cerebral cortex
Figure 6 Cerebral cortex
(Glial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4902/16166_B_9_5.jpg
Figure 7 Thyroid gland
Figure 7 Thyroid gland
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4902/16166_B_3_5.jpg
Figure 8 Colon
Figure 8 Colon
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4902/16166_A_8_3.jpg
Figure 9 Kidney
Figure 9 Kidney
(Cells in glomeruli
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4902/16166_A_8_5.jpg
Figure 10 Testis
Figure 10 Testis
(Pachytene spermatocytes
Staining:High
Intensity: Strong
Quantity:>75%
Preleptotene spermatocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Round or early spermatids
Staining:Medium
Intensity: Strong
Quantity: <25%
Spermatogonia cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4902/16166_A_5_6.jpg
Figure 11 Lymph node
Figure 11 Lymph node
(Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4902/16166_A_9_8.jpg
RNA Expression
Figure 12 RNA cell line category: Low cell line specificity
Figure 12 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000122565-CBX3

Specifications

  • Immunogen
  • Recombinant full length protein of human CBX3
  • Host Species
  • Mouse
  • Type
  • Mouse IgG
  • Specificity
  • Human CBX3
  • Species Reactivity
  • Human
  • Applications
  • WB, ELISA
  • Conjugate
  • Unconjugated

Product Property

  • Purification
  • Protein G affinity purified
  • Purity
  • >95% as determined by SDS-PAGE
  • Format
  • Liquid
  • Concentration
  • 1 mg/mL (lot specific)
  • Buffer
  • 50% Glycerol, 1% BSA, PBS, pH7.4.
  • Preservative
  • 0.02% sodium azide
  • Storage
  • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • This antibody has been tested for use in ELISA (1:5000-1:20000), Western Blot (1:100-1:2000).

Target

  • Alternative Names
  • HECH; HP1-GAMMA; HP1Hs-gamma
  • Cellular Localization
  • Nucleus
  • Post Translation Modifications
  • Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
  • Function
  • Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).

Recommended Products

Isotype Control

Secondary Antibody

Recommended Dilution Buffer

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "CBX3"

Fab Fragment Antibody

CAT Product Name Application Type
DrMAB-271 Human Anti-CBX3 Recombinant Antibody (clone D243); Fab Fragment IP, ELISA, IP-MS Human Fab

Recombinant Antibody

CAT Product Name Application Type
MOB-2405MZ Recombinant Mouse Anti-Human CBX3 Antibody ICC/IF, IHC-P, WB Mouse antibody
MRO-0766-CN Rabbit Anti-CBX3 Recombinant Antibody (clone JU81-36) WB, IHC, FC, IP Rabbit IgG
MOB-0038F Mouse Anti-CBX3 Recombinant Antibody (clone 2F5) IF, WB, IHC-P Mouse IgG
ZG-0443J Mouse Anti-CBX3 Recombinant Antibody (ZG-0443J) WB, ICC Mouse IgG
VS3-WK923 Mouse Anti-CBX3 Recombinant Antibody (VS3-WK923) WB, IHC Mouse IgG

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0496 Hi-Affi™ Rabbit Anti-CBX3 Recombinant Antibody (clone DS496AB) WB, FC Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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