Mouse Anti-CCRL2 Recombinant Antibody (clone BZ2E3) (CAT#: FAMAB-1584CQ)
This product is a recombinant mouse antibody that recognizes CCRL2. The antibody was purified by affinity chromatography. It can be used in FuncS, ICC, IP, WB, ELISA, FC, IHC.
Specific Inquiry
FC
Figure 1 Mast cells express mCCRL2.
Generation of anti-mCCRL2 specific mAbs. Unlabeled mCCRL2/L1.2 transfectants were mixed 1:1 with CMFDA-labeled CCR10/L1.2 transfectants and used to identify mCCRL2-specific mAbs by flow cytometry.
Zabel, B. A., Nakae, S., Zúñiga, L., Kim, J. Y., Ohyama, T., Alt, C., ... & Butcher, E. C. (2008). Mast cell–expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis. The Journal of experimental medicine, 205(10), 2207-2220.
Figure 2 CCRL2 binds chemerin.
Chemerin blocks anti-CCRL2 mAb binding. Various concentrations of human chemerin or CCL2 were incubated with total peritoneal mast cells on ice for 5 min, followed by incubation with CCRL2-specific mAb BZ2E3 or anti-IgE and detected with secondary anti -rat PE or anti-mouse IgE PE.
Zabel, B. A., Nakae, S., Zúñiga, L., Kim, J. Y., Ohyama, T., Alt, C., ... & Butcher, E. C. (2008). Mast cell–expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis. The Journal of experimental medicine, 205(10), 2207-2220.
Specifications
- Immunogen
- The extracellular amino-terminal domain of mCCRL2
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Mouse CCRL2
- Species Reactivity
- Mouse
- Clone
- BZ2E3
- Applications
- FuncS, ICC, IP, WB, ELISA, FC, IHC
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CCRL2; chemokine (C-C motif) receptor-like 2; C-C chemokine receptor-like 2; CKRX; CRAM A; CRAM B; HCR; CRAM A; CCRL2; Chemokine (C-C motif) receptor like 2; Chemokine receptor CCR11; Chemokine receptor X; CKRX; CRAM B; CRAMA; CRAMB; FLJ55815; HCR; MGC116710; MGC34104; Putative MCP 1 chemokine receptor; OTTHUMP00000209758; OTTHUMP00000209759; chemokine receptor X; chemokine receptor CCR11; putative MCP-1 chemokine receptor; CRAM; CRAM-A; CRAM-B;
- UniProt ID
- O35457
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0378CT | Mouse Anti-CCRL2 Recombinant Antibody (clone NN0269-6B26) | FC | Mouse IgG2 |
| FAMAB-1583CQ | Mouse Anti-CCRL2 Recombinant Antibody (clone BZ5B8) | FuncS, ICC, IP, WB, ELISA, FC, IHC | Mouse IgG2a |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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