Human Anti-CD37 Recombinant Antibody (clone A2); Fab Fragment (CAT#: HPAB-AP033-YC-F(E))
The Fab is a human antibody fragment that exhibits specificity for CD37. The mAb A2 significantly inhibits the growth of lymphomas, specifically Ramos lymphomas. The antibody is the Fab fragment antibody format of the antibody, cat# HPAB-AP033-YC. The Fab fragment of an antibody is capable of binding to antigens independently of the Fc portion.
Specific Inquiry
Whole Blood Assay
-1.png)
Figure 1 Whole Blood Assay: Effect of Antibodies A2 and B2 ON Viable CLL Cells.
Whole blood samples from CLL patients were incubated with increasing concentrations (0.001 μg/ml to 100 μg/ml) of antibodies A2 and B2 for 3 hours. The percentage of viable CLL cells at the end of the incubation period in relation to antibody concentration is depicted, curves represent mean of 11 individual patient samples. Standard deviation for each concentration tested is indicated. A2: filled triangle; B2: open triangle. Dotted line represents activity of an isotype matched control antibody.
Whole Blood Assay
-2.png)
Figure 2 Whole Blood Assay with CLL Patient Samples: Comparison of Different Antibodies.
Blood samples were incubated with 10 μg/ml of antibodies A2, B2, rituximab, alemtuzumab and an isotype matched control antibody for 3 hours. The percentage of viable CLL cells at the end of the incubation period is depicted, bars represent mean of 11 patient samples. Standard deviation is indicated. Dotted line represents activity of the isotype matched control antibody.
Whole Blood Assay
-3.png)
Figure 3 Whole Blood Assay with CLL Patient Samples: Comparison of Different Patient Subgroups.
Blood samples are incubated with 10 μg/ml of antibodies A2, B2, rituximab and alemtuzumab for 3 hours. The percentage of viable CLL cells at the end of the incubation period for different patient subgroups is depicted, bars represent mean of the indicated number of patient samples. Standard deviation is indicated.
Whole Blood Assay
-4.png)
Figure 4 Whole Blood Assay with CLL Patient Samples: Comparison of Different Patient Subgroups.
Blood samples from normal risk patients (n=11) and high risk patients (n=10) were incubated with 10 μg/ml of antibodies A2, B2, rituximab and alemtuzumab for 8 hours. The percentage of viable CLL cells at the end of the incubation period for the two patient subgroups is depicted, bars represent mean values, standard deviation is indicated.
-5.png)
Figure 5 Binding to FCγ-Receptor 3A
The affinity of antibodies A2 and B2 to Fcγ-receptor 3a is determined by surface plasmon resonance analysis (SFP).
Specifications
- Host Species
- Human
- Type
- Human Fab
- Specificity
- Human CD37
- Species Reactivity
- Human
- Clone
- A2
- Applications
- FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for Function Assay. For details, refer to Published Data.
Target
- Alternative Names
- CD37 Molecule; Tetraspanin-26; CD37 Antigen; Tspan-26; TSPAN26; Cell Differentiation Antigen 37; Leukocyte Surface Antigen CD37; Leukocyte Antigen CD37; GP52-40
- Gene ID
- 951
- UniProt ID
- P11049
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-904 | Anti-Human CD37 Recombinant Antibody (Otlertuzumab) | ELISA, IP, FC, FuncS, Neut, IF, ICC | VH - V-kappa - CH2 - CH3 |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0272CL | Anti-Human CD37 Recombinant Antibody (chHH1.1,) | ELISA, WB | Chimeric (mouse/human) |
| TAB-0273CL | Anti-Human CD37 Recombinant Antibody (chHH1.3) | Block | Chimeric (mouse/human) |
| TAB-0272CL-S(P) | Anti-Human CD37 Recombinant Antibody scFv Fragment (chHH1.1,) | ELISA, WB | Chimeric (mouse/human) |
| TAB-0273CL-S(P) | Anti-Human CD37 Recombinant Antibody scFv Fragment (chHH1.3) | Block | Chimeric (mouse/human) |
| TAB-0272CL-F(E) | Anti-Human CD37 Recombinant Antibody Fab Fragment (chHH1.1,) | ELISA, WB | Chimeric (mouse/human) |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0492CT | Mouse Anti-CD37 Recombinant Antibody (clone 3C9) | ELISA, IF, WB | Mouse IgG1 |
| HPAB-0159-FY | Mouse Anti-CD37 Recombinant Antibody (HPAB-0159-FY) | Activ, Depletion, FuncS, Inhib | Mouse IgG2a |
| HPAB-0163-FY | Mouse Anti-CD37 Recombinant Antibody (HPAB-0163-FY) | FC, Inhib, FuncS | Mouse IgG |
| HPAB-0901-WJ | Mouse Anti-CD37 Recombinant Antibody (clone HH1) | FC | Human IgG |
| ZG-0384F | Mouse Anti-CD37 Recombinant Antibody (ZG-0384F) | IF, ELISA | Mouse IgG |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-467CQ | Anti-Human CD37 Recombinant Antibody (Lilotomab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0159-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0159-FY-F(E)) | Activ, Depletion, FuncS, Inhib | Mouse Fab |
| HPAB-0163-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0163-FY-F(E)) | FC, Inhib | Mouse Fab |
| HPAB-0164-FY-F(E) | Mouse Anti-CD37 Recombinant Antibody; Fab Fragment (HPAB-0164-FY-F(E)) | FC, Inhib | Mouse Fab |
| HPAB-1045-FY-S(P) | Human Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-1045-FY-S(P)) | FC, ELISA | Human scFv |
| HPAB-1046-FY-S(P) | Human Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-1046-FY-S(P)) | FC, ELISA | Human scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-467CQ | Afuco™ Anti-CD37 ADCC Recombinant Antibody (Lilotomab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP033-YC-S(P) | Human Anti-CD37 Recombinant Antibody (clone A2); scFv Fragment | FuncS | Human scFv |
| HPAB-AP034-YC-S(P) | Human Anti-CD37 Recombinant Antibody (clone B2); scFv Fragment | FuncS | Human scFv |
| HPAB-0004-SJF-S(P) | Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0004-SJF-S(P)) | ELISA, IHC, FuncS | Mouse scFv |
| HPAB-0006-SJF-S(P) | Mouse Anti-CD37 Recombinant Antibody (clone A0); scFv Fragment | FACS, FuncS | Mouse scFv |
| HPAB-0009-SJF-S(P) | Human Anti-CD37 Recombinant Antibody (clone CAS-024); scFv Fragment | FuncS | Humanized scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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