Rat Anti-Cd8b1 Recombinant Antibody (clone YTS156.7.7); Fab Fragment (CAT#: HPAB-S0182-YC-F(E))
The YTS156.7 mAb inhibits this interaction and blocks T cell activation. To elucidate the molecular basis for this inhibition, the crystal structure of the CD8alphabeta immunoglobulin-like ectodomains were determined in complex with mAb YTS156.7 Fab at 2.7 A resolution. The YTS156.7 epitope on CD8beta was identified and implies that residues in the CDR1 and CDR2-equivalent loops of CD8beta are occluded upon binding to class I pMHC.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line CACO-2
(Immunofluorescent staining of human cell line CACO-2 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29164/1526_E8_1_selected.jpg
(Immunofluorescent staining of human cell line CACO-2 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29164/1526_E8_1_selected.jpg
Figure 2 High expression in lymph node.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4353/165972_A_9_8_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4353/165972_A_9_8_val_selected.jpg
Figure 3 Low expression in liver.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4353/165972_A_9_4_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4353/165972_A_9_4_val_selected.jpg
Figure 4 Lymph node
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4353/165972_A_9_8.jpg
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4353/165972_A_9_8.jpg
Figure 5 RNA cell line category: Cell line enriched (RPMI-8226)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000172116-CD8B
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000172116-CD8B
Specifications
- Host Species
- Rat
- Type
- Rat Fab
- Specificity
- Mouse CD8B
- Species Reactivity
- Mouse
- Clone
- YTS156.7.7
- Applications
- Neut
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1604MZ | Recombinant Mouse Anti-Rat CD8B Antibody (clone 452) | FC, IHC-P, IP, WB | Mouse antibody |
| FN-198CQ | Mouse Anti-CD8B Recombinant Antibody (clone 341) | Neut, FC, FuncS, IHC-P | Mouse IgG1, κ |
| HPAB-S0182-YC | Rat Anti-Cd8b1 Recombinant Antibody (clone YTS156.7.7) | Neut | Rat IgG |
| FAMAB-1681CQ | Mouse Anti-CD8B Recombinant Antibody (clone YTS 156.7.7) | FC, IHC | Mouse IgG2a |
| VS-0224-XY29 | Monkey Anti-CD8B Recombinant Antibody (VS-0224-XY29) | Depletion, In vivo assay | Monkey IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-435CQ | Rat Anti-CD8B Recombinant Antibody (clone 53-5.8) | Depletion, Block, IF | Rat IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0591 | Hi-Affi™ Rabbit Anti-CD8B Recombinant Antibody (clone DS591AB) | ICC, IF, WB | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0012-CN-S(P) | Mouse Anti-CD8B Recombinant Antibody (clone EP42); scFv Fragment | FC | Mouse scFv |
| HPAB-S0182-YC-S(P) | Rat Anti-Cd8b1 Recombinant Antibody (clone YTS156.7.7); scFv Fragment | Neut | Rat scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0012-CN-F(E) | Mouse Anti-CD8B Recombinant Antibody (clone EP42); Fab Fragment | FC | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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