Human Anti-CDH6 Recombinant Antibody (clone Ab-HKT288) (CAT#: PABC-397)
This product is a recombinant Human antibody that can recognize CDH6.
Specific Inquiry
FuncS
Figure 1 HKT288 elicits target dependent anti-tumor efficacy in PDX models of Renal Clear Cell Carcinoma.
A Human renal clear cell carcinomas display a range of % CDH6 positive tumor area as determined by quantitative IHC. Three example, PDX models of renal clear cell carcinoma within this range are shown: HKIX3629, HKIX3717, and HKIX5374. B Representative CDH6 IHC image of each RCC carcinoma PDX model. C RCC carcinoma PDX models HKIX3629, HKIX3717, and HKIX5374 were grown subcutaneously in female nude mice until they reached an appropriate tumor volumel then were treated q2w i.v. with either vehicle, IgG1-sulfo-SPDB-DM4 5 mg/kg, HKT288 at 2.5 mg/kg or 5 mg/kg. Tumor size versus time post-implant is shown.
Bialucha, C. U., Collins, S. D., Li, X., Saxena, P., Zhang, X., Dürr, C., ... & Lee, D. (2017). Discovery and Optimization of HKT288, a Cadherin-6–Targeting ADC for the Treatment of Ovarian and Renal Cancers. Cancer discovery, 7(9), 1030-1045.
Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human CDH6
- Species Reactivity
- Human
- Clone
- Ab-HKT288
- Applications
- ELISA, FC
- Related Disease
- Ovarian or renal cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The use of antibody Ab-HKT288 in Functional Assay, Enzyme-linked Immunosorbent Assay and Flow Cytometry has been reported. It is recommended that the optimal antibody concentration, dilution, incubation time, etc. should be carefully titrated in a specific assay.
Target
- Alternative Names
- Cadherin 6, Type 2, K-Cadherin (Fetal Kidney); K-Cadherin; Kidney Cadherin; CAD6; KCAD
- Gene ID
- 1004
- UniProt ID
- P55285
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone Ab-HKT288"
See other products for "CDH6"
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-405LC | Human Anti-CDH6 Recombinant Antibody (TAB-405LC) | ELISA, FC | Human IgG |
| TAB-405LC-S(P) | Human Anti-CDH6 Recombinant Antibody; scFv Fragment (TAB-405LC-S(P)) | ELISA, FC | Human scFv |
| TAB-405LC-F(E) | Human Anti-CDH6 Recombinant Antibody; Fab Fragment (TAB-405LC-F(E)) | ELISA, FC | Human Fab |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0621 | Hi-Affi™ Rabbit Anti-CDH6 Recombinant Antibody (clone DS621AB) | WB, IP | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-397 | Human Anti-CDH6 Recombinant Antibody (clone Ab-HKT288); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0391-FY-F(E) | Human Anti-CDH6 Recombinant Antibody; Fab Fragment (HPAB-0391-FY-F(E)) | FC, ELISA, Activ | Human Fab |
| HPAB-0392-FY-F(E) | Human Anti-CDH6 Recombinant Antibody; Fab Fragment (HPAB-0392-FY-F(E)) | FC, ELISA, Activ | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-397 | Human Anti-CDH6 Recombinant Antibody (clone Ab-HKT288); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0391-FY-S(P) | Human Anti-CDH6 Recombinant Antibody; scFv Fragment (HPAB-0391-FY-S(P)) | FC, ELISA, Activ | Human scFv |
| HPAB-0392-FY-S(P) | Human Anti-CDH6 Recombinant Antibody; scFv Fragment (HPAB-0392-FY-S(P)) | FC, ELISA, Activ | Human scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0391-FY | Human Anti-CDH6 Recombinant Antibody (HPAB-0391-FY) | FC, ELISA, Activ | Human IgG |
| HPAB-0392-FY | Human Anti-CDH6 Recombinant Antibody (HPAB-0392-FY) | FC, ELISA, Activ | Human IgG |
| ZG-0979F | Mouse Anti-CDH6 Recombinant Antibody (clone 2B6) | ICC, IHC-Fr, IHC-P, WB | Mouse IgG1 |
| VS-0723-WK69 | Human Anti-CDH6 Recombinant Antibody (VS-0723-WK69) | FC | Chimeric (rabbit/human) IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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