Mouse Anti-CLDN1 Recombinant Antibody (clone PT0509) (CAT#: VS3-CJ195)
This product is a mouse antibody that recognizes CLDN1.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Liver
(Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_A_8_4.jpg
(Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_A_8_4.jpg
Figure 2 Kidney
(Bowman's capsule
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_A_8_5.jpg
(Bowman's capsule
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_A_8_5.jpg
Figure 3 Testis
(Pachytene spermatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Round or early spermatids
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Sertoli cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_A_5_6.jpg
(Pachytene spermatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Round or early spermatids
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Sertoli cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_A_5_6.jpg
Figure 4 Skin
(Cells in granular layer
Staining:High
Intensity: Strong
Quantity:>75%
Cells in spinous layer
Staining:High
Intensity: Strong
Quantity:>75%
Hair follicles
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_B_9_1.jpg
(Cells in granular layer
Staining:High
Intensity: Strong
Quantity:>75%
Cells in spinous layer
Staining:High
Intensity: Strong
Quantity:>75%
Hair follicles
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48319/122918_B_9_1.jpg
Figure 5 RNA cell line category: Group enriched (EFO-21, HaCaT, hTCEpi, RPTEC TERT1, RT4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163347-CLDN1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163347-CLDN1
Specifications
- Immunogen
- Synthesized peptide derived from human Claudin 1
- Host Species
- Mouse
- Specificity
- Human CLDN1
- Species Reactivity
- Human
- Clone
- PT0509
- Applications
- IHC-P, WB
- Conjugate
- Unconjugated
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.5% BSA, PBS.
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- CLD1; SEMP1; ILVASC
- Gene ID
- 9076
- UniProt ID
- O95832
- Sequence Similarities
- Belongs to the claudin family.
- Cellular Localization
- Cell junction, Cell membrane Membrane, Tight junction
- Protein Refseq
- NP_066924.1
- Function
- Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).
(Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes (PubMed:17325668, PubMed:20375010, PubMed:24038151).
Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell (PubMed:20375010).
Acts as a receptor for dengue virus (PubMed:24074594).
Recommended Products
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CLDN1"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-594-VHH | Recombinant Anti-Human CLDN1 VHH Single Domain Antibody | WB, IP, ICC, FC, FA | Llama VHH |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-479LC | Anti-Human CLDN1 Recombinant Antibody (3A2) | FC, ELISA, IB, Inhib, IF | |
| TAB-480LC | Anti-Human CLDN1 Recombinant Antibody (2C1) | FC, ELISA, IB, Inhib, IF | |
| TAB-481LC | Anti-Human CLDN1 Recombinant Antibody (5F2) | FC, ELISA, IB, Inhib, IF | |
| TAB-482LC | Anti-Human CLDN1 Recombinant Antibody (7A5) | FC, ELISA, IB, Inhib, IF | |
| TAB-483LC | Mouse Anti-CLDN1 Recombinant Antibody (TAB-483LC) | FC, FuncS, IP, WB | Mouse IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0716 | Hi-Affi™ Rabbit Anti-CLDN1 Recombinant Antibody (clone DS716AB) | IHC-P | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0080-LS | Mouse Anti-CLDN1 Recombinant Antibody (HPAB-0080-LS) | WB, FC, IF, IP, Inhib | Mouse IgG |
| HPAB-M0488-YC | Rat Anti-CLDN1 Recombinant Antibody (HPAB-M0488-YC) | FC, Inhib, FuncS | Rat IgG2b, κ |
| HPAB-M0489-YC | Human Anti-CLDN1 Recombinant Antibody (HPAB-M0489-YC) | FC, Inhib, FuncS | Humanized IgG |
| VS3-QX245 | Mouse Anti-CLDN1 Recombinant Antibody (clone 8G1) | WB, IP, IF, IHC | Mouse IgG1 |
| VS3-XY3317 | Rabbit Anti-CLDN1 Recombinant Antibody (clone R09-5K9) | WB | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0080-LS-S(P) | Mouse Anti-CLDN1 Recombinant Antibody; scFv Fragment (HPAB-0080-LS-S(P)) | WB, FC, IF, IP, Inhib | Mouse scFv |
| HPAB-M0488-YC-S(P) | Rat Anti-CLDN1 Recombinant Antibody; scFv Fragment (HPAB-M0488-YC-S(P)) | FC, Inhib, FuncS | Rat scFv |
| HPAB-M0489-YC-S(P) | Human Anti-CLDN1 Recombinant Antibody; scFv Fragment (HPAB-M0489-YC-S(P)) | FC, Inhib, FuncS | Humanized scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0080-LS-F(E) | Mouse Anti-CLDN1 Recombinant Antibody; Fab Fragment (HPAB-0080-LS-F(E)) | WB, FC, IF, IP, Inhib | Mouse Fab |
| HPAB-M0488-YC-F(E) | Rat Anti-CLDN1 Recombinant Antibody; Fab Fragment (HPAB-M0488-YC-F(E)) | FC, Inhib, FuncS | Rat Fab |
| HPAB-M0489-YC-F(E) | Human Anti-CLDN1 Recombinant Antibody; Fab Fragment (HPAB-M0489-YC-F(E)) | FC, Inhib, FuncS | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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