Rabbit Anti-CLU Recombinant Antibody (clone R07-4K8) (CAT#: VS3-XY3320)
This product is a recombinant rabbit antibody that recognizes CLU (Clusterin), which prevents stress-induced aggregation of blood plasma proteins. It specifically reacts with human and mouse CLU. This antibody has been reported for use in Western Blot and Immunohistochemistry-Paraffin. The recommended dilutions of Western Blot and Immunohistochemistry-Paraffin is 1/500-1/1000 and 1/50-1/100, respectively.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75983/1919_G12_2_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75983/1919_G12_2_selected.jpg
Figure 2 IF staining of human cell line A549
(Immunofluorescent staining of human cell line A549 shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75983/2064_D2_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line A549 shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75983/2064_D2_1_blue_red_green.jpg
Figure 3 Cerebral cortex
(Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/572/1519_B_7_5.jpg
(Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/572/1519_B_7_5.jpg
Figure 4 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/572/1519_A_6_6.jpg
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/572/1519_A_6_6.jpg
Figure 5 Epididymis
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/572/1519_A_3_6.jpg
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/572/1519_A_3_6.jpg
Figure 6 RNA cell line category: Cell line enhanced (HeLa, SK-BR-3, T-47d, U-2 OS)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120885-CLU
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120885-CLU
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse CLU
- Species Reactivity
- Human, Mouse
- Clone
- R07-4K8
- Applications
- WB, IHC-P
- Related Disease
- Scrapie; Anaplastic Large Cell Lymphoma
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
Target
- Alternative Names
- CLI; AAG4; APOJ; CLU1; CLU2; KUB1; SGP2; APO-J; SGP-2; SP-40; TRPM2; TRPM-2; NA1/NA2
- Gene ID
- 1191
- UniProt ID
- P10909
- Long Name
- Clusterin
- Cellular Localization
- Nucleus, Cytoplasm, Mitochondrion membrane, Cytosol, Microsome
- Post Translation Modifications
- Glycosylation at Ser210, Asn86, Asn103, Asn145, Asn291, Asn354, and Asn374 (NX_P10909 [NX_P10909-1])
Modification sites at PhosphoSitePlus (P10909)
Glycosylation from GlyConnect CLUS_HUMAN (759)
Glycosylation from GlyGen (P10909) 12 sites, 158 N-linked glycans (6 sites), 3 O-linked glycans (4 sites)
- Protein Refseq
- NP_001822.3
- Function
- Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CLU"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-690-VHH | Recombinant Anti-Human CLU VHH Single Domain Antibody | ICC, FC, WB, FUNC | Llama VHH |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-178CL | Human Anti-CLU Recombinant Antibody (TAB-178CL) | FuncS, Inhib | Human IgG2 |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-533LC | Mouse Anti-CLU Recombinant Antibody (TAB-533LC) | WB | Mouse IgG |
| TAB-533LC-S(P) | Mouse Anti-CLU Recombinant Antibody; scFv Fragment (TAB-533LC-S(P)) | WB | Mouse scFv |
| TAB-533LC-F(E) | Mouse Anti-CLU Recombinant Antibody; Fab Fragment (TAB-533LC-F(E)) | WB | Mouse Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0455MZ | Recombinant Mouse Anti-Rat CLU Antibody (clone 0.U.20) | WB | Mouse antibody |
| HPAB-0203-YC | Mouse Anti-CLU Recombinant Antibody (HPAB-0203-YC) | ELISA, FC, RIA | Mouse IgG |
| HPAB-0204-YC | Human Anti-CLU Recombinant Antibody (HPAB-0204-YC) | ELISA, FC, RIA | Humanized IgG |
| ZG-0619J | Rabbit Anti-CLU Recombinant Antibody (clone 2A1) | ELISA, IHC | Rabbit IgG |
| VS-0723-WK113 | Human Anti-CLU Recombinant Antibody (VS-0723-WK113) | FC | Chimeric (rabbit/human) IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0735 | Hi-Affi™ Rabbit Anti-CLU Recombinant Antibody (clone DS735AB) | IHC-P, WB | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0203-YC-S(P) | Mouse Anti-CLU Recombinant Antibody; scFv Fragment (HPAB-0203-YC-S(P)) | ELISA, FC, RIA | Mouse scFv |
| HPAB-0204-YC-S(P) | Human Anti-CLU Recombinant Antibody; scFv Fragment (HPAB-0204-YC-S(P)) | ELISA, FC, RIA | Humanized scFv |
| HPAB-0440LY-S(P) | Human Anti-CLU Recombinant Antibody; scFv Fragment (HPAB-0440LY-S(P)) | ELISA, RIA, FC | Humanized scfv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0203-YC-F(E) | Mouse Anti-CLU Recombinant Antibody; Fab Fragment (HPAB-0203-YC-F(E)) | ELISA, FC, RIA | Mouse Fab |
| HPAB-0204-YC-F(E) | Human Anti-CLU Recombinant Antibody; Fab Fragment (HPAB-0204-YC-F(E)) | ELISA, FC, RIA | Humanized Fab |
| HPAB-0440LY-F(E) | Human Anti-CLU Recombinant Antibody; Fab Fragment (HPAB-0440LY-F(E)) | ELISA, RIA, FC | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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