Human Anti-CMV gB Recombinant Antibody (clone 1/22) (CAT#: FAMAB-0247JF)
Recombinant monoclonal antibody specially binds to the N-terminal part (NETIYNTTLKYGDV) of HVMV gB. This human anti-HCMV gB antibody (1/22) may contribute to the treatment or prophylaxis of HCMV disease due to resistant strains and treatment of side e¡ects of antiviral drugs.
Specific Inquiry
WB
Figure 1 Western blotting and immunoprecipitation analysis of mAb 1/22.
Western blotting was carried out for cell lysates (50 µg/sample) of the MRC-5, Towne, and AD169 strains.
Jun, F., Minhuan, L., Yadan, M., Yaping, H., Hanying, L., Jianhua, H., ... & Weihang, M. (2012). Development of two potential diagnostic monoclonal antibodies against human cytomegalovirus glycoprotein B. Brazilian Journal of Medical and Biological Research, 45(7), 583-590.
ELISA
Figure 2 Isotypes and final indirect ELISA screening of mAb1/22.
Individual hybridoma culture supernatants (1:1 dilution with PBS) were added to detect reactivity.
Jun, F., Minhuan, L., Yadan, M., Yaping, H., Hanying, L., Jianhua, H., ... & Weihang, M. (2012). Development of two potential diagnostic monoclonal antibodies against human cytomegalovirus glycoprotein B. Brazilian Journal of Medical and Biological Research, 45(7), 583-590.
IHC
Figure 3 Immunohistochemical (IHC) staining of human cytomegalovirus (HCMV)-infected MRC-5 cells using mAb.
Normal MRC-5 cells were infected with HCMV strains Towne and AD169 at an MOI of 1.0 for 3 days at 37°C.
Jun, F., Minhuan, L., Yadan, M., Yaping, H., Hanying, L., Jianhua, H., ... & Weihang, M. (2012). Development of two potential diagnostic monoclonal antibodies against human cytomegalovirus glycoprotein B. Brazilian Journal of Medical and Biological Research, 45(7), 583-590.
Specifications
- Host Species
- Human
- Derivation
- Human phage display scFv library
- Type
- Human IgG
- Specificity
- CMV gB
- Species Reactivity
- HCMV
- Clone
- 1/22
- Applications
- WB, ELISA, IHC
- Related Disease
- HCMV infection
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The CMV gB antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Immunohistochemistry.
Target
- Alternative Names
- CMV gB; Cytomegalovirus glycoprotein B; HCMV; HCMV glycoprotein B; HHV-5; Human herpesvirus 5; UL55
- Function
- Neutralizing HCMV
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-221-S(P) | Recombinant Anti-CMV gB Antibody scFv Fragment | ELISA, WB, Neut, FuncS | scFv |
| FAMAB-0102WJ-S(P) | Human Anti-CMV gB Recombinant Antibody (clone ITC33); scFv Fragment | ELISA | Human scFv |
| FAMAB-0103WJ-S(P) | Human Anti-CMV gB Recombinant Antibody (clone ITC39); scFv Fragment | ELISA | Human scFv |
| FAMAB-0104WJ-S(P) | Human Anti-CMV gB Recombinant Antibody (clone ITC48); scFv Fragment | ELISA | Human scFv |
| FAMAB-0248JF-S(P) | Human Anti-CMV gB Recombinant Antibody (clone 2/4); scFv Fragment | ELISA, FuncS | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-221-F(E) | Recombinant Human Anti-CMV gB Antibody Fab Fragment | ELISA, WB, FC, FuncS | Fab |
| FAMAB-0102WJ-F(E) | Human Anti-CMV gB Recombinant Antibody (clone ITC33); Fab Fragment | ELISA | Human Fab |
| FAMAB-0103WJ-F(E) | Human Anti-CMV gB Recombinant Antibody (clone ITC39); Fab Fragment | ELISA | Human Fab |
| FAMAB-0247JF-F(E) | Human Anti-CMV gB Recombinant Antibody (clone 1/22); Fab Fragment | ELISA, FuncS | Human Fab |
| FAMAB-0248JF-F(E) | Human Anti-CMV gB Recombinant Antibody (clone 2/4); Fab Fragment | ELISA, FuncS | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1489CQ | Recombinant Mouse Anti-CMV gB Antibody (0826) | ELISA, IF, WB | Mouse antibody |
| MRO-1490CQ | Recombinant Mouse Anti-CMV gB Antibody (1.B.222) | WB, IF | Mouse antibody |
| MRO-1491CQ | Recombinant Mouse Anti-CMV gB Antibody (1.B.223) | WB, IF, ELISA | Mouse antibody |
| MRO-1492CQ | Recombinant Mouse Anti-CMV gB Antibody (1116580) | ICC, WB, ELISA | Mouse antibody |
| MRO-1493CQ | Recombinant Mouse Anti-CMV gB Antibody (1204) | ICC | Mouse antibody |
MHC Tetramer for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF063 | DRB1*07:01/CMV gB (PDDYSNTHSTRYVTV) MHC Monomer | MHC Multimer |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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