Human Anti-CMV gB Recombinant Antibody (clone 2/4) (CAT#: FAMAB-0248JF)
Recombinant monoclonal antibody specially binds to the C-terminal part (VTSGSTKD) of HVMV gB. This human anti-HCMV gB antibody (2/4) can be potentially used in the treatment of HCMV infection, such as AIDS patients and transplant recipients.
Specific Inquiry
IF
Figure 1 Immunofluorescent staining localizing HCMV protein expression in HCMV-infected HF at 5 dpi.
The transporting vacuole and the plasma membrane to release its content to the extracellular space.
Homman-Loudiyi, M., Hultenby, K., Britt, W., & Söderberg-Nauclér, C. (2003). Envelopment of human cytomegalovirus occurs by budding into Golgi-derived vacuole compartments positive for gB, Rab 3, trans-Golgi network 46, and mannosidase II. Journal of virology, 77(5), 3191-3203.
ELISA
Figure 2 Blocking of the epitope recognized by biotinylated ITC52 in membrane preparations of CMV-infected human fibroblasts by human monoclonal antibodies.
M058 and M061, which served as negative controls, are human antibodies (IgGl) recognizing CMV pp65.
Ohlin, M., Sundqvist, V. A., Mach, M. I. C. H. A. E. L., Wahren, B., & Borrebaeck, C. A. (1993). Fine specificity of the human immune response to the major neutralization epitopes expressed on cytomegalovirus gp58/116 (gB), as determined with human monoclonal antibodies. Journal of Virology, 67(2), 703-710.
WB
Figure 3 Determination of carbohydrate involvement in gB epitopes recognized by human monoclonal antibodies.
The antigen had been enzymatically deglycosylated prior to SDS-PAGE and Western blot.
Ohlin, M., Sundqvist, V. A., Mach, M. I. C. H. A. E. L., Wahren, B., & Borrebaeck, C. A. (1993). Fine specificity of the human immune response to the major neutralization epitopes expressed on cytomegalovirus gp58/116 (gB), as determined with human monoclonal antibodies. Journal of Virology, 67(2), 703-710.
Specifications
- Host Species
- Human
- Derivation
- Human phage display scFv library
- Type
- Human IgG
- Specificity
- CMV gB
- Species Reactivity
- HCMV
- Clone
- 2/4
- Applications
- WB, ELISA, IF
- Related Disease
- HCMV infection
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The CMV gB antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Immunofluorescence.
Target
- Alternative Names
- CMV gB; Cytomegalovirus glycoprotein B; HCMV; HCMV glycoprotein B; HHV-5; Human herpesvirus 5; UL55
- Function
- Neutralizing HCMV
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone 2/4"
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-221 | Recombinant Anti-CMV gB Antibody | ELISA, WB, IF, FuncS | IgG |
| MHH-221 | Recombinant Human Anti-CMV gB Antibody | Neut, WB, FuncS | IgG |
| MRO-1506CQ | Recombinant Mouse Anti-CMV gB Antibody (CH446) | IF | Mouse antibody |
| MRO-1507CQ | Recombinant Mouse Anti-CMV gB Antibody (CH51) | IF | Mouse antibody |
| MRO-1579CQ | Recombinant Mouse Anti-CMV gB Antibody (1F11) | WB | Mouse antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-221-F(E) | Recombinant Anti-CMV gB Antibody Fab Fragment | IF, FC, FuncS | Fab |
| MHH-221-F(E) | Recombinant Human Anti-CMV gB Antibody Fab Fragment | ELISA, WB, FC, FuncS | Fab |
| FAMAB-0102WJ-F(E) | Human Anti-CMV gB Recombinant Antibody (clone ITC33); Fab Fragment | ELISA | Human Fab |
| FAMAB-0247JF-F(E) | Human Anti-CMV gB Recombinant Antibody (clone 1/22); Fab Fragment | ELISA, FuncS | Human Fab |
| FAMAB-0248JF-F(E) | Human Anti-CMV gB Recombinant Antibody (clone 2/4); Fab Fragment | ELISA, FuncS | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-221-S(P) | Recombinant Human Anti-CMV gB Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
| FAMAB-0102WJ-S(P) | Human Anti-CMV gB Recombinant Antibody (clone ITC33); scFv Fragment | ELISA | Human scFv |
| FAMAB-0103WJ-S(P) | Human Anti-CMV gB Recombinant Antibody (clone ITC39); scFv Fragment | ELISA | Human scFv |
| FAMAB-0104WJ-S(P) | Human Anti-CMV gB Recombinant Antibody (clone ITC48); scFv Fragment | ELISA | Human scFv |
| FAMAB-0248JF-S(P) | Human Anti-CMV gB Recombinant Antibody (clone 2/4); scFv Fragment | ELISA, FuncS | Human scFv |
MHC Tetramer for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF063 | DRB1*07:01/CMV gB (PDDYSNTHSTRYVTV) MHC Monomer | MHC Multimer |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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