Recombinant Human Anti-DENV Antibody (MAb 1A5) (CAT#: HPAB-0154CQ)
This product is a recombinant human antibody that recognizes DENV. The antibody can bind and neutralize dengue type 1, 2, 3, and 4 virus.
Specific Inquiry
WB
Figure 1 Analysis of antigen specificity by radioimmunoprecipitation.
Radioactive 35S-methionine-labeled lysates separately prepared from Vero cells infected with each of the DENV serotypes (D1 to D4) were used for immuneprecipitation with Fab 1A5 or Fab 1A10. Lane M, molecular mass markers in kilodaltons. Each of the Fabs precipitated the E protein of each of four DENV serotypes. Note that the E protein often migrated as a doublet or a broad band, probably resulting from differences in glycosylation.
Goncalvez, A. P., Men, R., Wernly, C., Purcell, R. H., & Lai, C. J. (2004). Chimpanzee Fab fragments and a derived humanized immunoglobulin G1 antibody that efficiently cross-neutralize dengue type 1 and type 2 viruses. Journal of virology, 78(23), 12910-12918.
FuncS
Figure 2 In vitro neutralization of DENVs and other flaviviruses by humanized IgG1 1A5.
The neutralizing activity of IgG1 1A5 against DENV-1 strain Hawaii, DENV-2 strain New Guinea B, DENV-3 strain H87, DENV-4 strain 814669, JEV vaccine strain SA14-14-2, LGTV strain TP 21, and the WNV/DENV-4 chimera was analyzed by a PRNT.
Goncalvez, A. P., Men, R., Wernly, C., Purcell, R. H., & Lai, C. J. (2004). Chimpanzee Fab fragments and a derived humanized immunoglobulin G1 antibody that efficiently cross-neutralize dengue type 1 and type 2 viruses. Journal of virology, 78(23), 12910-12918.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Human IgG1
- Specificity
- DENV DENV
- Species Reactivity
- DENV
- Clone
- MAb 1A5
- Applications
- ELISA, Neut, WB, FuncS
- Related Disease
- Dengue and other flaviviruses-associated diseases
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot and Functional Assay. Please see the Published Data for further information.
Target
- Alternative Names
- DENV; Dengue virus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-937 | Human Anti-DENV Recombinant Antibody (clone YC090); scFv Fragment | ELISA, PP, IF, Inhib | Human scFv |
| HPAB-1281LY-S(P) | Mouse Anti-DENV Recombinant Antibody; scFv Fragment (HPAB-1281LY-S(P)) | Neut, IHC, ELISA | Mouse scFv |
| HPAB-0128-YJ-S(P) | Human Anti-DENV Recombinant Antibody; scFv Fragment (HPAB-0128-YJ-S(P)) | ELISA, Neut, FuncS | Humanized scFv |
| HPAB-0129-YJ-S(P) | Human Anti-DENV Recombinant Antibody; scFv Fragment (HPAB-0129-YJ-S(P)) | ELISA, Neut, FuncS | Humanized scFv |
| HPAB-2089LY-S(P) | Mouse Anti-DENV Recombinant Antibody; scFv Fragment (HPAB-2089LY-S(P)) | ELISA, RIA, WB | Mouse scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-416CQ | Recombinant Mouse Anti-DENV Antibody (5161) | ELISA | Mouse antibody |
| MRO-417CQ | Recombinant Mouse Anti-DENV Antibody (5E260) | ELISA | Mouse antibody |
| MRO-418CQ | Recombinant Mouse Anti-DENV Antibody (9.F.10) | WB, IF, IHC-P | Mouse antibody |
| MRO-419CQ | Recombinant Mouse Anti-DENV Antibody (BDI419) | Dot, ELISA, IF | Mouse antibody |
| MRO-420CQ | Recombinant Mouse Anti-DENV Antibody (D1-11(3)) | Dot, ELISA, IF, WB | Mouse antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0128-YJ-F(E) | Human Anti-DENV Recombinant Antibody; Fab Fragment (HPAB-0128-YJ-F(E)) | ELISA, Neut, FuncS | Humanized Fab |
| HPAB-0129-YJ-F(E) | Human Anti-DENV Recombinant Antibody; Fab Fragment (HPAB-0129-YJ-F(E)) | ELISA, Neut, FuncS | Humanized Fab |
| HPAB-N0060-YC-F(E) | Mouse Anti-DENV Recombinant Antibody; Fab Fragment (HPAB-N0060-YC-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-N0061-YC-F(E) | Mouse Anti-DENV Recombinant Antibody; Fab Fragment (HPAB-N0061-YC-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-N0062-YC-F(E) | Human Anti-DENV Recombinant Antibody; Fab Fragment (HPAB-N0062-YC-F(E)) | ELISA, FuncS | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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