This product is a recombinant human antibody that recognizes DENV4 E. The antibody was purified by affinity chromatography. It can be used in Neut, WB, ELISA, FC.
Figure 1 Three mAbs neutralize all four DENV serotypes by binding two distinct epitopes on each virus.
Three mAbs (all IgG1) were selected for their specificity and neutralizing activity: DV87.1 binds DIII of DENV-1, −2 and −3; DV22.3 binds DI/DII of DENV-4, and DV82.11 cross-reacts with DI/DII of all DENV serotypes. (A) Neutralization (○) and enhancement (●) of infection by recombinant unmodified mAbs. (B) Neutralization (○) and enhancement (●) of infection by engineered LALA variant mAbs. Nonlinear regression analysis was used to calculate the EC50, indicated in the panel. Data are mean of duplicates. One representative experiment out of three performed. (C) A cocktail of LALA-mAbs (DV82.11= 2 µg/ml, DV87.1=DV22.3= 0.2 µg/ml) was used in combination with mAbs directed against prM (DV69.6) or DI/DII E protein (DV78.6) or serum from a primary DENV-infected donor at potent enhancing concentration (0.1 µg/ml) on K562 cells.
Beltramello, M., Williams, K. L., Simmons, C. P., Macagno, A., Simonelli, L., Quyen, N. T. H., ... & Sallusto, F. (2010). The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity. Cell host & microbe, 8(3), 271-283.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-1118LC | Human Anti-DENV4 E Recombinant Antibody (MRO-1118LC) | ELISA | Human IgG |
MRO-1118LC-S(P) | Human Anti-DENV4 E Recombinant Antibody; scFv Fragment (MRO-1118LC-S(P)) | ELISA | Human scFv |
MRO-1118LC-F(E) | Human Anti-DENV4 E Recombinant Antibody; Fab Fragment (MRO-1118LC-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-1125LC-S(P) | Anti-DENV4 E Recombinant Antibody scFv Fragment (1A5) | ELISA | Chimpanzee antibody |
MRO-1126LC-S(P) | Anti-DENV4 E Recombinant Antibody scFv Fragment (2H7) | ELISA | Chimpanzee antibody |
MRO-1127LC-S(P) | Anti-DENV4 E Recombinant Antibody scFv Fragment (2H5) | ELISA | Chimpanzee antibody |
MRO-1128LC-S(P) | Anti-DENV4 E Recombinant Antibody scFv Fragment (3A2) | ELISA | Chimpanzee antibody |
MRO-1129LC-S(P) | Anti-DENV4 E Recombinant Antibody scFv Fragment (MRO-1129LC-S(P)) | ELISA | Chimpanzee antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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