Recombinant monoclonal antibody specially binds to desmoglein 3 (Dsg3). This human anti-Dsg3 antibody PVMAB786 can e a useful reagent to study the mechanism of cell adhesion and detachment on tumor biology, specifically squamous cell carcinomas.
Figure 1 Oral disease severity in pemphigus vulgaris (PV) and pemphigus foliaceus (PF) plotted against desmoglein (Dsg) 3 antibody levels measured by enzyme-linked immunosorbent assay (ELISA).
Median and quartile values are marked with red and green lines, respectively.
Harman, K. E., Seed, P. T., Gratian, M. J., Bhogal, B. S., Challacombe, S. J., & Black, M. M. (2001). The severity of cutaneous and oral pemphigus is related to desmoglein 1 and 3 antibody levels. British Journal of Dermatology, 144(4), 775-780.
Figure 2 Novel antigens recognized significantly differentially by pemphigus vulgaris (PV) antibodies.
The signal intensities of differentially reactive proteins associated with PV.
Kalantari‐Dehaghi, M., Molina, D. M., Farhadieh, M., John Morrow, W., Liang, X., Felgner, P. L., & Grando, S. A. (2011). New targets of pemphigus vulgaris antibodies identified by protein array technology. Experimental dermatology, 20(2), 154-156.
Figure 3 The expression profiles for the keratoconus samples (gray) and the controls (white) normalized to GAPDH.
Sample numbers are shown at the bottom.
Nielsen, K., Heegaard, S., Vorum, H., Birkenkamp-Demtröder, K., Ehlers, N., & Orntoft, T. F. (2005). Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients. Cornea, 24(6), 661-668.
Figure 4 Antibody staining against DSG3.
The granular localization of S100A2 is visible in a reference sample.
Nielsen, K., Heegaard, S., Vorum, H., Birkenkamp-Demtröder, K., Ehlers, N., & Orntoft, T. F. (2005). Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients. Cornea, 24(6), 661-668.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-258MZ | Anti-Human DSG3 Recombinant Antibody (DF151) | IHC, FC | |
TAB-259MZ | Anti-Human DSG3 Recombinant Antibody (DF364) | IHC, FC | |
TAB-258MZ-F(E) | Anti-Human DSG3 Recombinant Antibody Fab Fragment (DF151) | IHC, FC | |
TAB-259MZ-F(E) | Anti-Human DSG3 Recombinant Antibody Fab Fragment (DF364) | IHC, FC | |
TAB-260MZ-F(E) | Anti-Human DSG3 Recombinant Antibody Fab Fragment (DF366) | IHC, FC |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1055 | Hi-Affi™ Rabbit Anti-DSG3 Recombinant Antibody (clone DS1055AB) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0203-CN-S(P) | Human Anti-DSG3 Recombinant Antibody (clone (D3)1b/3a); scFv Fragment | ELISA, IF, IB | Human scFv |
FAMAB-0204-CN-S(P) | Human Anti-DSG3 Recombinant Antibody (clone (D3);3c/9); scFv Fragment | ELISA, IF, IB | Human scFv |
FAMAB-0205-CN-S(P) | Human Anti-DSG3 Recombinant Antibody (clone (D3)3a/9); scFv Fragment | ELISA, IF, IB | Human scFv |
FAMAB-0152JF-S(P) | Human Anti-DSG3 Recombinant Antibody (clone PVMAB786); scFv Fragment | IF, WB, ELISA, FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0203-CN-F(E) | Human Anti-DSG3 Recombinant Antibody (clone (D3)1b/3a); Fab Fragment | ELISA, IF, IB | Human Fab |
FAMAB-0204-CN-F(E) | Human Anti-DSG3 Recombinant Antibody (clone (D3)3c/9); Fab Fragment | ELISA, IF, IB | Human Fab |
FAMAB-0205-CN-F(E) | Human Anti-DSG3 Recombinant Antibody (clone (D3)3a/9); Fab Fragment | ELISA, IF, IB | Human Fab |
FAMAB-0152JF-F(E) | Human Anti-DSG3 Recombinant Antibody (clone PVMAB786); Fab Fragment | IF, WB, ELISA, FuncS | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
VS3-QX332 | Mouse Anti-DSG3 Recombinant Antibody (clone 1G6A7) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
VS3-QX333 | Mouse Anti-DSG3 Recombinant Antibody (clone 11G-2C) | WB, IHC, FC | Mouse IgG1 |
VS3-XY593 | Mouse Anti-DSG3 Recombinant Antibody (clone 6G2C11) | ELISA, WB, IHC, FC | Mouse IgG1 |
VS3-XY594 | Mouse Anti-DSG3 Recombinant Antibody (clone 6G2E2) | ELISA, WB, IHC, FC | Mouse IgG1 |
VS4-WK149 | Mouse Anti-DSG3 Recombinant Antibody (clone 4C2) | ELISA | Mouse IgG1 |
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