Mouse Anti-ERBB3 Recombinant Antibody (clone 15D5) (CAT#: HPAB-0436-FY)
This product is a recombinant antibody that recognizes Human ERBB3. The monoclonal antibody 15D5 reacts with the epitope of ERBB3. The anti-HER3 15D5 antibodies inhibited heregulin induced HER3 phosphorylation in the BxPC3.
Specific Inquiry
Inhib
Figure 1 Inhibition of heregulin induced human HER3 receptor phosphorylation with anti-HER3 antibodies in BxPC3 pancreatic cancer cells.
FC
Figure 2 The murine 15D5 antibody (M5.15D5.1C1) cross-reacts with murine HER3 expressed on B16F10 cells.
Inhib
Figure 3 The murine 1D9 antibody (M5.1D9.1F5), the murine 15D5 antibody (M5.15D5.2A1), the murine24H5 antibody (M5.24H5.C2), the chimeric 1D9 antibody and the chimeric 15D5 antibody inhibit heregulin induced BxPC3 pancreatic cancer cell invasion.
FuncS
Figure 4 The murine 15D5 antibody (M5.15D5.2A1.H10) and humanized 1D9 antibody induced receptor internalization in human CHL-1 melanoma cells.
FuncS
Figure 5 Efficacy of mouse anti-HER3 mAb, murine 1D9 antibody, in the B 16F10 syngeneic tumor model.
FuncS
Figure 6 Efficacy of mouse anti-HER3 mAb, murine 15D5 antibody, in the CHL-1 xenograft model.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human ERBB3
- Species Reactivity
- Human
- Clone
- 15D5
- Applications
- Inhib
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Functional Assay, Flow Cytometry, Inhibition.
Target
- Alternative Names
- Erb-B2 Receptor Tyrosine Kinase 3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; Tyrosine Kinase-Type Cell Surface Receptor HER3; Human Epidermal Growth Factor Receptor 3; Proto-Oncogene-Like Protein C-ErbB-3; EC 2.7.10.1; HER3; Lethal Congenital Contracture Syndrome 2; Receptor Tyrosine-Protein Kinase ErbB-3; P180-ErbB3;
- Gene ID
- 2065
- UniProt ID
- P21860
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 15D5"
See other products for "ERBB3"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1729-sdAb | Recombinant Anti-human ERBB3 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| TAB-070CT | Llama Anti-ERBB3 Recombinant Single Domain Antibody (TAB-070CT) | FC, Block | Llama VHH |
| PABC-556 | Recombinant Llama Anti-ERBB3 Single Domain Antibody (PABC-556) | ELISA, SPR | Llama VHH |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L074E | HRGβ2-PE immunotoxin | Cytotoxicity assay, Functional assay |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-086 | Human Anti-ERBB3 Recombinant Antibody (clone KTN3379) | ELISA, WB, IF, FuncS | Human IgG |
| HPAB-0022-WJ | Human Anti-ERBB3 Recombinant Antibody (HPAB-0022-WJ) | ELISA, Inhib, WB, FuncS | Human IgG1, λ |
| HPAB-0024-WJ | Human Anti-ERBB3 Recombinant Antibody (HPAB-0024-WJ) | ELISA | Human IgG1 |
| HPAB-0025-WJ | Human Anti-ERBB3 Recombinant Antibody (HPAB-0025-WJ) | ELISA | Human IgG1 |
| HPAB-0220-FY | Human Anti-ERBB3 Recombinant Antibody (clone Hu-E14) | ELISA, WB | Humanized IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-086 | Human Anti-ERBB3 Recombinant Antibody (clone KTN3379); scFv Fragment | ELISA, WB, IF, FuncS | Human scFv |
| HPAB-0608-WJ-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (HPAB-0608-WJ-S(P)) | ELISA, IHC | Humanized scFv |
| HPAB-0609-WJ-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (HPAB-0609-WJ-S(P)) | ELISA, IHC | Humanized scFv |
| HPAB-1695-FY-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-1695-FY-F(E)) | ELISA | Human Fab |
| HPAB-1696-FY-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-1696-FY-F(E)) | ELISA | Human Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0048CL-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-0048CL-F(E)) | ELISA, FuncS, Inhib, FC | Human Fab |
| TAB-0049CL-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-0049CL-F(E)) | ELISA, FuncS, Inhib, FC | Human Fab |
| TAB-0050CL-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-0050CL-F(E)) | ELISA, FuncS, Inhib, FC | Human Fab |
| TAB-065CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-065CT-F(E)) | ELISA, FC | Human Fab |
| TAB-066CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-066CT-F(E)) | ELISA, Inhibion, FC | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0508CL-F(E) | Anti-Human ERBB3 Recombinant Antibody Fab Fragment (1A5) | ELISA, Inhib, FuncS | |
| TAB-0509CL-F(E) | Anti-Human ERBB3 Recombinant Antibody Fab Fragment (3D4) | ELISA, Inhib, FuncS | |
| TAB-060CT | Rabbit Anti-ERBB3 Recombinant Antibody (TAB-060CT) | Inhib, ELISA | Rabbit IgG |
| TAB-064CT-S(P) | Mouse Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-064CT-S(P)) | ELISA, FC | Mouse scFv |
| TAB-067CT-S(P) | Anti-Human HER3 Recombinant Antibody scFv Fragment (5101) | ELISA, Inhibition, FC |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-061CT | Human Anti-ERBB3 Recombinant Antibody (TAB-061CT) | Inhib, ELISA | Chimeric (Rabbit/Human) antibody |
| TAB-061CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-061CT-S(P)) | Inhib, ELISA | Human scFv |
| TAB-061CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-061CT-F(E)) | Inhib, ELISA | Chimeric (Rabbit/Human) Fab |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-063CT | Human Anti-ERBB3 Recombinant Antibody (TAB-063CT) | IF, WB, Inhib, ELISA | Humanized antibody |
| TAB-057CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-057CT-S(P)) | Inhibion, ELISA | Humanized scFv |
| TAB-058CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-058CT-S(P)) | WB, ELISA, Inhib | Human scFv |
| TAB-059CT-S(P) | Anti-Human HER3 Recombinant Antibody scFv Fragment (LMAb3) | WB, ELISA, Inhibition, FC | Humanized antibody |
| TAB-057CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-057CT-F(E)) | Inhibion, ELISA | Humanized Fab |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-738CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone CBL932) | Neut, IP | Mouse IgG1 |
| NEUT-739CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone CBL483) | FC, CyTOF®, ELISA, Neut | Mouse IgG1 |
| NEUT-740CQ | Human Anti-ERBB3 Recombinant Antibody (clone CBL1019) | Neut | Human IgG1, κ |
| NEUT-741CQ | Human Anti-ERBB3 Recombinant Antibody (clone CBL1020) | Neut | Human IgG1, κ |
| NEUT-742CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone M908) | Neut | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1179 | Hi-Affi™ Rabbit Anti-ERBB3 Recombinant Antibody (clone DS1179AB) | ICC, IF, WB | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0286-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 1153); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
| HPAB-0287-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 920104); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
| HPAB-0288-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 1126); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
| HPAB-0289-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 12511); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
| HPAB-0290-YC-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (HPAB-0290-YC-F(E)) | ELISA, FuncS, FC | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H21 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-422CQ | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Elgemtumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, BL | ADCC enhanced antibody |
| AFC-TAB-189 | Afuco™ Anti-ERBB3 Recombinant Antibody (AFC-TAB-189), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | Human IgG1, κ |
| AFC-TAB-H22 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotuzumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| AFC-TAB-892 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Seribantumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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