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  • Rabbit Anti-EXOSC2 Recombinant Antibody (clone R02-7D6)

Rabbit Anti-EXOSC2 Recombinant Antibody (clone R02-7D6) (CAT#: VS3-FY1873)

Clone R02-7D6 is a rabbit recombinant antibody that is designed to recognize human EXOSC2 protein, a calculated weight of 33 kDa. It cross-reacts with mouse, rat.
The following recommendations serve as a starting point for assay optimization. The actual working concentration may vary and should be determined by the user. The R02-7D6 is recommended for detection of target protein by western blotting (dilution range 1:500-1:1000).


See more Engineered Antibody products for EXOSC2
Specific Inquiry
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  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21756/1444_D10_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21790/48768_B_8_5.jpg
Figure 3 Colon
Figure 3 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21790/48768_A_7_3.jpg
Figure 4 Liver
Figure 4 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21790/48768_A_7_4.jpg
Figure 5 Kidney
Figure 5 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21790/48768_A_8_5.jpg
Figure 6 Testis
Figure 6 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21790/48768_A_5_6.jpg
Figure 7 Lymph node
Figure 7 Lymph node
(Germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21790/48768_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000130713-EXOSC2

Specifications

  • Immunogen
  • Synthetic peptide of human RRP4
  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human, Mouse and Rat EXOSC2
  • Species Reactivity
  • Human, Mouse, Rat
  • Clone
  • R02-7D6
  • Applications
  • Western Blot
  • MW
  • The calculated weight of the target protein is approximately 33 kDa, while the observed molecular weight stands at 33 kDa.
  • Related Disease
  • Short Stature, Hearing Loss, Retinitis Pigmentosa, And Distinctive Facies and Retinitis Pigmentosa

Product Property

  • Purification
  • Affinity Purified
  • Format
  • Liquid
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • Western Blot: 1/500-1/1000

Target

  • Alternative Names
  • Exosome Component 2; Homolog Of Yeast RRP4 (Ribosomal RNA Processing 4), 3 5 Exoribonuclease (RRP4); Ribosomal RNA-Processing Protein 4; RRP4; Homolog Of Yeast RRP4 (Ribosomal RNA Processing 4), 3-5-Exoribonuclease; Exosome Complex Exonuclease RRP4
  • Sequence Similarities
  • Belongs to the RRP4 family.
  • Cellular Localization
  • Cytoplasm, Exosome, Nucleus
  • Post Translation Modifications
  • Ubiquitination at Lys24 and Lys180 (NX_Q13868 [NX_Q13868-1])
    Modification sites at PhosphoSitePlus (Q13868)
    Glycosylation from GlyGen (Q13868) 1 site, 1 O-linked glycan (1 site)
  • Function
  • The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.

Recommended Products

Isotype Control

Secondary Antibody

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "EXOSC2"

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1215 Hi-Affi™ Rabbit Anti-EXOSC2 Recombinant Antibody (clone DS1215AB) ICC, IF, IP, IHC-P, WB Rabbit IgG

Recombinant Antibody

CAT Product Name Application Type
ZG-407C Mouse Anti-EXOSC2 Recombinant Antibody (clone 15B3) ELISA, IB, IP Mouse IgG1

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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