Human Anti-F8 Recombinant Antibody (clone KM41) (CAT#: FAMAB-0200JF)
Recombinant monoclonal antibody specially binds to A3-C1 domains of factor VIII. This human anti-F8 antibody (KM41) is dependent on residues R1803-K1818, which contain a binding site for factor IXa. In view of the similar epitope specificity of scFv KM41 and CLB-CAg A, it is likely that scFv KM41 competes with factor IXa for binding to the factor VIII light chain.
Specific Inquiry
IP
Figure 1 Binding of scFv to recombinant factor VIII/factor V light-chain hybrids was assessed by immunoprecipitation.
Reactivity of isolated scFv with factor VIII/factor V light-chain hybrids.
van den Brink, E. N., Turenhout, E. A., Bovenschen, N., Heijnen, B. G., Mertens, K., Peters, M., & Voorberg, J. (2001). Multiple VH genes are used to assemble human antibodies directed toward the A3-C1 domains of factor VIII. Blood, 97(4), 966–972.
SPR
Figure 2 Kinetic parameters for binding of factor VIII light chain to immobilized scFv.
Response is indicated as resonance units (RU) and is corrected for nonspecific binding.
van den Brink, E. N., Turenhout, E. A., Bovenschen, N., Heijnen, B. G., Mertens, K., Peters, M., & Voorberg, J. (2001). Multiple VH genes are used to assemble human antibodies directed toward the A3-C1 domains of factor VIII. Blood, 97(4), 966–972.
Specifications
- Host Species
- Human
- Derivation
- Human phage display scFv library
- Type
- Human IgG
- Specificity
- Human F8
- Species Reactivity
- Human
- Clone
- KM41
- Applications
- WB, ELISA, FuncS
- Related Disease
- Hemophilia A
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-930-VHH | Recombinant Anti-Human F8 VHH Single Domain Antibody | ELISA, Neut, ICC, FC | Llama VHH |
Rat Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-259CL | Human Anti-F8 Recombinant Antibody (TAB-259CL) | ELISA | Human IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-044 | Human Anti-F8 Recombinant Antibody (clone BO2C11); scFv Fragment | Neut | Human scFv |
| HPAB-1242WJ-S(P) | Human Anti-F8 Recombinant Antibody (clone YK3.3.40); scFv Fragment | ELISA | Human scFv |
| HPAB-1243WJ-S(P) | Human Anti-F8 Recombinant Antibody (clone YK3.3.50); scFv Fragment | ELISA | Human scFv |
| FAMAB-0201JF-S(P) | Human Anti-F8 Recombinant Antibody (clone KM38); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| FAMAB-0287JF-S(P) | Human Anti-F8 Recombinant Antibody (clone VK41); scFv Fragment | ELISA, FuncS | Human scFv |
Mouse Antibody
Fab Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-014LC | Recombinant Anti-Human F8 Antibody (Fab glycosylation) | ELISA | Human antibody |
Deglycosylated Antibody (Non-glycosylated IgGs)
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-015LC | Recombinant Anti-Human F8 Antibody (Non-glycosylated) | ELISA | Human antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-058 | Recombinant Human Anti-F8 Antibody (BO2C11) | WB, ELISA, FuncS, Inhib, PK, IP, SPR | IgG |
| PABX-058-S (P) | Recombinant Human Anti-F8 Antibody scFv Fragment (BO2C11) | WB, ELISA, FuncS | scFv |
| PABX-058-F (E) | Recombinant Human Anti-F8 Antibody Fab Fragment (BO2C11) | WB, ELISA, FuncS | Fab |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-765CQ | Mouse Anti-F8 Recombinant Antibody (clone CBL215) | ELISA, WB, Neut | Mouse IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1229 | Hi-Affi™ Rabbit Anti-F8 Recombinant Antibody (clone DS1229AB) | ELISA | Rabbit IgG |
| MOR-4166 | Hi-Affi™ Rabbit Anti-F8 Recombinant Antibody (clone SI243DS) | ELISA | Rabbit IgG |
| MOR-4167 | Hi-Affi™ Rabbit Anti-F8 Recombinant Antibody (clone SI244DS) | ELISA | Rabbit IgG |
Epitope-Specific Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0611LC | Human Anti-F8 Recombinant Antibody (clone BO2C11) | ELISA | Human IgG4 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0096-YC-F(E) | Human Anti-F8 Recombinant Antibody (clone YK3.3.38); Fab Fragment | ELISA, FuncS | Human Fab |
| HPAB-0178CQ-F(E) | Mouse Anti-F8 Recombinant Antibody; Fab Fragment (HPAB-0178CQ-F(E)) | ELISA, DB, Inhib | Mouse Fab |
| HPAB-1977-FY-F(E) | Human Anti-F8 Recombinant Antibody (clone 92-137); Fab Fragment | Inhib | Human Fab |
| HPAB-1978-FY-F(E) | Human Anti-F8 Recombinant Antibody (clone 92-102); Fab Fragment | Inhib | Human Fab |
| HPAB-1979-FY-F(E) | Human Anti-F8 Recombinant Antibody (clone WR8); Fab Fragment | IP | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1977-FY | Human Anti-F8 Recombinant Antibody (clone 92-137) | Inhib | Human IgG |
| HPAB-1978-FY | Human Anti-F8 Recombinant Antibody (clone 92-102) | Inhib | Human IgG |
| HPAB-1979-FY | Human Anti-F8 Recombinant Antibody (clone WR8) | IP | Human IgG4 |
| HPAB-1980-FY | Human Anti-F8 Recombinant Antibody (clone WR11) | IP | Human IgG4 |
| HPAB-1981-FY | Human Anti-F8 Recombinant Antibody (clone WR10) | IP | Human IgG4 |
MHC Tetramer for Other Applications
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF075 | DRB1*11:01/Factor VIII Factor VIII (ENIQRFLPNPAGVQLEDPEF) MHC Monomer | MHC Multimer |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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