Human Anti-FN1 Recombinant Antibody (clone G4) (CAT#: FAMAB-1143CQ)

Figure 1 Extradomain-B Fibronectin (EDB-FN) overexpression in invasive breast cancer.

Strong EDB-FN staining observed in adjacent tissue (NAT), and metastases in lung.

Vaidya, A., Wang, H., Qian, V., Gilmore, H., & Lu, Z. R. (2020). Overexpression of extradomain-B fibronectin is associated with invasion of breast cancer cells. Cells, 9(8), 1826.

Figure 2 Extradomain-B Fibronectin (EDB-FN) overexpression in invasive breast cancer.

3D cultures of the cancer cell lines stained with EDB-FN-specific ZD2-Cy5.5 probe show higher EDB-FN expression in the invasive cell lines than in MCF7 cells, demonstrating direct correlation with their invasive pattern.

Vaidya, A., Wang, H., Qian, V., Gilmore, H., & Lu, Z. R. (2020). Overexpression of extradomain-B fibronectin is associated with invasion of breast cancer cells. Cells, 9(8), 1826.

Figure 3 Depletion of EDB-FN and SRp55 in invasive TGF-β-treated and drug-resistant breast cancer cells reduces their invasion.

TGF-β-treated and drug-resistant MCF7 and MDA-MB-468 cells were treated with ECO/siNC (siN), ECO/siEDB (siE), and ECO/siSRSF6 (siS) nanoparticles at 100 nM [siRNA] and N/P = 10.

Vaidya, A., Wang, H., Qian, V., Gilmore, H., & Lu, Z. R. (2020). Overexpression of extradomain-B fibronectin is associated with invasion of breast cancer cells. Cells, 9(8), 1826.