Human Anti-Ganglioside GD3 Recombinant Antibody (clone MB3.6) (CAT#: HPAB-1247WJ)
This product is a human antibody targeting Human Ganglioside GD3. This antibody can be used inn the treatment of cancers expressing this antigen.
Specific Inquiry
Cyt
Figure 1 MAb MB3.6-mediated cytotoxicity of human melanoma cells in the presence of human complement.
The specific lysis was determined for five human melanoma cell lines that were labeled with 51Cr and challenged with MAb MB3.6 in the presence of human complement as described.
Cheresh, D. A., Honsik, C. J., Staffileno, L. K., Jung, G., & Reisfeld, R. A. (1985). Disialoganglioside GD3 on human melanoma serves as a relevant target antigen for monoclonal antibody-mediated tumor cytolysis. Proceedings of the National Academy of Sciences, 82(15), 5155-5159.
ADCC
Figure 2 ADCC of M21 human melanoma cells mediated by Mab MB3.6 and effector cells from patients with melanoma.
The specific lysis was determined for M21 human melanoma cells that were labeled with 51Cr and challenged with human peripheral blood mononuclear cells isolated from three patients with advanced melanoma or one normal individual.
Cheresh, D. A., Honsik, C. J., Staffileno, L. K., Jung, G., & Reisfeld, R. A. (1985). Disialoganglioside GD3 on human melanoma serves as a relevant target antigen for monoclonal antibody-mediated tumor cytolysis. Proceedings of the National Academy of Sciences, 82(15), 5155-5159.
ADCC
Figure 3 ADCC of human melanoma target cells mediated by MAb MB3.6 and normal human effector cells.
Cheresh, D. A., Honsik, C. J., Staffileno, L. K., Jung, G., & Reisfeld, R. A. (1985). Disialoganglioside GD3 on human melanoma serves as a relevant target antigen for monoclonal antibody-mediated tumor cytolysis. Proceedings of the National Academy of Scices, 82(15), 5155-5159.
Inhib
Figure 4 Effects of MAb MB3.6 on the growth of A375p human melanoma cells expressing small amounts of GD3.
Cheresh, D. A., Honsik, C. J., Staffileno, L. K., Jung, G., & Reisfeld, R. A. (1985). Disialoganglioside GD3 on human melanoma serves as a relevant target antigen for monoclonal antibody-mediated tumor cytolysis. Proceedings of the National Academy of Scices, 82(15), 5155-5159.
Inhib
Figure 5 Effects of MAb MB3.6 on human melanoma tumor formation in nude mice.
Cheresh, D. A., Honsik, C. J., Staffileno, L. K., Jung, G., & Reisfeld, R. A. (1985). Disialoganglioside GD3 on human melanoma serves as a relevant target antigen for monoclonal antibody-mediated tumor cytolysis. Proceedings of the National Academy of Scices, 82(15), 5155-5159.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human Ganglioside GD3
- Species Reactivity
- Human
- Clone
- MB3.6
- Applications
- Cyt, ADCC, Inhib
- Related Disease
- Tumors
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The Ganglioside GD3 antibody has been reported in applications of Cytotoxicity, Antibody-dependent Cell-mediated Cytotoxicity, Inhibition.
Target
- Alternative Names
- Ganglioside
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1247WJ-S(P) | Human Anti-Ganglioside GD3 Recombinant Antibody (clone MB3.6); scFv Fragment | ELISA | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1247WJ-F(E) | Human Anti-Ganglioside GD3 Recombinant Antibody (clone MB3.6); Fab Fragment | ELISA | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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