Human Anti-GJB2 Recombinant Antibody (clone abEC1.1); Fab Fragment (CAT#: PFBC-396)
This product is a recombinant Human antibody Fab fragment that can recognize Connexin26. The antibody binds an extracellular epitope of Cx26. abEC1.1 inhibits connexin hemichannels by binding an epitope at the apex of the EC1 loop.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line RT4
(Immunofluorescent staining of human cell line RT4 shows localization to mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14362/1560_F3_3_selected.jpg
(Immunofluorescent staining of human cell line RT4 shows localization to mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14362/1560_F3_3_selected.jpg
Figure 2 Esophagus
(Squamous epithelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13093/33277_B_6_1.jpg
(Squamous epithelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13093/33277_B_6_1.jpg
Figure 3 Colon
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13093/33277_A_8_3.jpg
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13093/33277_A_8_3.jpg
Figure 4 Liver
(Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13093/33277_A_8_4.jpg
(Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13093/33277_A_8_4.jpg
Figure 5 Testis
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13093/33277_A_6_6.jpg
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13093/33277_A_6_6.jpg
Figure 6 RNA cell line category: Group enriched (CAPAN-2, hTCEpi, OE19, RT4)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165474-GJB2
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165474-GJB2
Specifications
- Immunogen
- A peptide corresponding to residues 41-56 of Cx26
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human Fab
- Specificity
- Human GJB2
- Species Reactivity
- Human
- Clone
- abEC1.1
- Applications
- ELISA, WB, IF, Inhib
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Connexin 26; Cx26; HID; KID; PPK; DFNA3; DFNB1; NSRD1; DFNA3A; DFNB1A
- Gene ID
- 2706
- UniProt ID
- P29033
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2985z | Mouse Anti-GJB2 Recombinant Antibody (clone 24H11) | WB, ELISA, IHC | Mouse IgG1, κ |
| PABC-396 | Human Anti-GJB2 Recombinant Antibody (clone abEC1.1) | ELISA, WB, IF, Inhib | Human IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-396 | Human Anti-GJB2 Recombinant Antibody (clone abEC1.1); scFv Fragment | ELISA, WB, IF, Inhib | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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