Recombinant monoclonal antibody specially binds to amino acids 129-142 (QTLQDPRVRGLYFP) of the pre-S domain. This mouse anti-pre-S2 antibody (1F6) can to potentially used in the treatment of patients with HBV infection.
Figure 1 Duration of anti-HBs antibody responses in baboons vaccinated at weeks 4.
Data represent group geometric mean anti-HBs antibody concentration measured by EIA (Abbott).
Traquina, P., Morandi, M., Contorni, M., & Van Nest, G. (1996). MF59 adjuvant enhances the antibody response to recombinant hepatitis B surface antigen vaccine in primates. Journal of Infectious Diseases, 174(6), 1168-1175.
Figure 2 The schematic presentation of the preS2 deletion variant found in two different patients.
HBV DNA as expected from the nonenveloped nucleocapsid particles.
Tai, P. C., Suk, F. M., Gerlich, W. H., Neurath, A. R., & Shih, C. (2002). Hypermodification and immune escape of an internally deleted middle-envelope (M) protein of frequent and predominant hepatitis B virus variants. Virology, 292(1), 44-58.
Figure 3 S envelope proteins in preS2 deletion variant-transfected cells.
The arrowhead indicates the glycosylated and nonglycosylated forms of L and S envelope proteins.
Tai, P. C., Suk, F. M., Gerlich, W. H., Neurath, A. R., & Shih, C. (2002). Hypermodification and immune escape of an internally deleted middle-envelope (M) protein of frequent and predominant hepatitis B virus variants. Virology, 292(1), 44-58.
Figure 4 Characterization of HBV-specific CD8+ and CD4+ T cells by flow cytometry.
Quantification of HBs-specific CD8+ T cells.
Mancini‐Bourgine, M., Fontaine, H., Scott‐Algara, D., Pol, S., Bréchot, C., & Michel, M. L. (2004). Induction or expansion of T‐cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriers. Hepatology, 40(4), 874-882.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-438 | Recombinant Anti-HBV PreS2 Antibody | ELISA, WB, FuncS | IgG |
MHH-438 | Recombinant Human Anti-HBV PreS2 Antibody | ELISA, IP, FuncS | IgG |
PABZ-054 | Recombinant Mouse Anti-HBV preS2 Antibody (F124) | WB, FuncS | IgG |
MRO-647CQ | Recombinant Mouse Anti-HBV preS2 Antibody (S9) | IHC-P, IHC-Fr, WB, ELISA, IF | Mouse antibody |
MRO-648CQ | Recombinant Mouse Anti-HBV preS2 Antibody (M0071926) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-438-F(E) | Recombinant Anti-HBV PreS2 Antibody Fab Fragment | WB, FuncS | Fab |
MHH-438-F(E) | Recombinant Human Anti-HBV PreS2 Antibody Fab Fragment | ELISA, WB, FC, FuncS | Fab |
PFBZ-054 | Recombinant Mouse Anti-HBV preS2 Antibody Fab Fragment (F124) | WB, FuncS | IgG |
FAMAB-0246JF-F(E) | Mouse Anti-HBV preS2 Recombinant Antibody (clone 1F6); Fab Fragment | ELISA, FuncS | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-438-S(P) | Recombinant Anti-HBV PreS2 Antibody scFv Fragment | WB, ELISA, IHC, FuncS | scFv |
MHH-438-S(P) | Recombinant Human Anti-HBV PreS2 Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
PSBW-054 | Recombinant Mouse Anti-HBV preS2 Antibody scFv Fragment (F124) | WB, ELISA | scFv |
FAMAB-0246JF-S(P) | Mouse Anti-HBV preS2 Recombinant Antibody (clone 1F6); scFv Fragment | ELISA, FuncS | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-462LC | Anti-HBV Pre-S2 Recombinant Antibody (H8) | ELISA | Mouse antibody |
MRO-462LC-S(P) | Anti-HBV Pre-S2 Recombinant Antibody scFv Fragment (H8) | ELISA | Mouse antibody |
MRO-462LC-F(E) | Anti-HBV Pre-S2 Recombinant Antibody Fab Fragment (H8) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-463LC | Anti-HBV Pre-S2 Recombinant Antibody (A-44) | ELISA | Chimeric antibody (mouse/human) |
MRO-463LC-S(P) | Anti-HBV Pre-S2 Recombinant Antibody scFv Fragment (A-44) | ELISA | Chimeric antibody (mouse/human) |
MRO-464LC-S(P) | Anti-HBV Pre-S2 Recombinant Antibody scFv Fragment (6-31) | ELISA | Chimeric antibody (mouse/human) |
MRO-463LC-F(E) | Anti-HBV Pre-S2 Recombinant Antibody Fab Fragment (A-44) | ELISA | Chimeric antibody (mouse/human) |
MRO-464LC-F(E) | Anti-HBV Pre-S2 Recombinant Antibody Fab Fragment (6-31) | ELISA | Chimeric antibody (mouse/human) |
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